• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Nrf2 in ocular neovascular disease

Research Project

Project/Area Number 24791875
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

NAGAI Norihiro  慶應義塾大学, 医学部, 助教 (10327611)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords網膜 / 炎症 / 酸化ストレス / nrf2
Research Abstract

Nrf2, a basic leucine zipper redox-sensitive transcription factor, regulates the inducible expression of antioxidant and cytoprotective genes by binding to the cis-acting enhancer sequence known as the antioxidant response element. We tested whether the Nrf2 is involved in regulating the vascular inflammation and oxidative damage in the retinal inflammation model. Retinal vascular inflammation was increased in Nrf2 deficient mice and Nrf2 protected retinal inflammation. Currently, the mainstay of therapy for diabetic retinopathy and age-related macular degeneration involves intravitreal injection of anti-vascular endothelial factor agents, which has limited effects. Treatment targeting the Nrf2 pathway may be a possible new therapy for these retinal vascular diseases.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2013 2012

All Journal Article (1 results) Presentation (7 results)

  • [Journal Article] ケールに含まれるルテインの加齢黄斑変性, ドライアイに対する作用2013

    • Author(s)
      永井紀博, 坪田一男, ホウレンソウ
    • Journal Title

      内分泌・糖尿病 ・ 代謝内科

      Volume: 第36巻第4号 Pages: 276-271

    • Related Report
      2013 Final Research Report
  • [Presentation] 抗 VEGF 療法に反応不良の滲出型加齢黄斑変性に対するアフリベルセプトの作用2013

    • Author(s)
      永井紀博
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢黄斑変性の治療戦略2013

    • Author(s)
      永井紀博
    • Organizer
      第131回広島県眼科医会講習会
    • Place of Presentation
      広島
    • Year and Date
      2013-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] レスベラトロールによる脈絡膜新生血管の抑制2013

    • Author(s)
      永井紀博
    • Organizer
      第117回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-04-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者における黄斑色素密度と血清カロテノイド濃度の相関2012

    • Author(s)
      永井紀博
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] レニン・アンジオテンシン系と炎症の抑制による網脈絡膜疾患の制御-動物モデルによる解析-2012

    • Author(s)
      永井紀博
    • Organizer
      第15回眼科若手研究者の会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 若年者における黄斑色素密度の検討2012

    • Author(s)
      小林文貴, 永井紀博
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-07
    • Related Report
      2013 Final Research Report
  • [Presentation] レスベラトロールによる脈絡膜新生血管の抑制2012

    • Author(s)
      永井紀博
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-07
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi