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To analyze the transport between the outer retina and the choroidal circulation in Age-related macular degeneration

Research Project

Project/Area Number 24791876
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

IZUMI-NAGAI Kanako  慶應義塾大学, 医学部, 共同研究員 (60407103)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords網膜脈絡膜物質輸送 / 加齢黄斑変性 / fenestrae / 脈絡膜毛細血管
Research Abstract

To analyze in vivo tracer transport through the murine choriocapillaris, cardiac or tail vein injection using dextran , NHS-Biotin or transferrin to wild mice was done. The leakage outside of the choriocapillaris was observed immediately after injection with NHS-Biotin. On the other hand, punctate staining pattern was observed using dextran (70KDa) or transferrin. These results suggested that transport of small molecule was fenestrae-dependent and that of large molecule was endocytosis-dependent.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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