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The mechanism of dry eye and secretory vesicles of the lacrimal gland

Research Project

Project/Area Number 24791877
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

KAMOI MIZUKA  慶應義塾大学, 医学部, 助教 (50348728)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords涙腺 / ドライアイ / 分泌顆粒 / VDT作業 / シェーグレン症候群
Outline of Final Research Achievements

In this study, we focused on a human VDT work-related dry eye. The lacrimal gland biopsy specimens from VDT-related dry eye patients were compared with specimens from Sjogren's syndrome patients and autopsied normal controls. The purpose of this study is to elucidate whether SV accumulation is involved in VDT work-related dry eye in human subjects. Our analysis of lacrimal gland showed that the increased SV accumulation. Based on our findings, we hypothesize a new mechanism for VDT work-related dry eye, in which a tear secretion disorder probably related to a decreased blinking rate leads to an excessive accumulation of SVs.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren' s type dry eye in visual display terminal users2012

    • Author(s)
      Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K.
    • Journal Title

      PLoS One

      Volume: 7巻 Issue: 9 Pages: 1-8

    • DOI

      10.1371/journal.pone.0043688

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 涙腺上皮細胞における分泌顆粒の過剰な貯留はVDT作業者の非シェーグレンタイプドライアイに関連する

    • Author(s)
      鴨居瑞加
    • Organizer
      第22回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      大阪ブリーゼプラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren's type dry eye in visual display terminal users

    • Author(s)
      鴨居瑞加
    • Organizer
      第67回日本臨床眼科学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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