The mechanism of dry eye and secretory vesicles of the lacrimal gland
| Project/Area Number |
24791877
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
KAMOI MIZUKA 慶應義塾大学, 医学部, 助教 (50348728)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 涙腺 / ドライアイ / 分泌顆粒 / VDT作業 / シェーグレン症候群 |
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| Outline of Final Research Achievements |
In this study, we focused on a human VDT work-related dry eye. The lacrimal gland biopsy specimens from VDT-related dry eye patients were compared with specimens from Sjogren's syndrome patients and autopsied normal controls. The purpose of this study is to elucidate whether SV accumulation is involved in VDT work-related dry eye in human subjects. Our analysis of lacrimal gland showed that the increased SV accumulation. Based on our findings, we hypothesize a new mechanism for VDT work-related dry eye, in which a tear secretion disorder probably related to a decreased blinking rate leads to an excessive accumulation of SVs.
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Report
(5 results)
Research Products
(3 results)
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[Journal Article] Accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-Sjogren' s type dry eye in visual display terminal users2012
Author(s)
Kamoi M, Ogawa Y, Nakamura S, Dogru M, Nagai T, Obata H, Ito M, Kaido M, Kawakita T, Okada Y, Kawakami Y, Shimmura S, Tsubota K.
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Journal Title
PLoS One
Volume: 7巻
Issue: 9
Pages: 1-8
DOI
Related Report
Peer Reviewed
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