The mechanism of corneal nerve regeneration associated with microglia
| Project/Area Number |
24791879
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 角膜 / 神経 / 角膜神経 / マクロファージ |
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| Research Abstract |
Recent studies have focused on the microglia for the maintenance of central nerve system. Cornea is endowed with highest density of nerve fiber in whole body. However, little is known about association between corneal nerve maintenance and other cells such as microglia in central nerve system. We hypothesis that cornea also have microglia like cells who have a capacity to repair corneal nerves in corneal injury. We found that there were microglia like cells in periphery of cornea and also found that P2Y2, which is ATP receptor known as expressing microglia, positive cells in peripheral cornea. Stimulation of P2Y2 by P2Y2 agonist showed significant acceleration of corneal nerve repair. We are continuing to study more precise mechanism of corneal nerve repair.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] In vivo challenging of polymyxins and levofloxacin eye drop against multidrug-resistant Pseudomonas aeruginosa keratitis.2014
Author(s)
Tajima K, Miyake T, Koike N, Hattori T, Kumakura S, Yamaguchi T, Matsumoto T, Fujita K, Kuroda M, Ito N, Goto H.
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Journal Title
J Infect Chemother.
Volume: 20
Issue: 6
Pages: 343-349
DOI
Related Report
Peer Reviewed
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