| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Recent studies have focused on the microglia for the maintenance of central nerve system. Cornea is endowed with highest density of nerve fiber in whole body. However, little is known about association between corneal nerve maintenance and other cells such as microglia in central nerve system. We hypothesis that cornea also have microglia like cells who have a capacity to repair corneal nerves in corneal injury. We found that there were microglia like cells in periphery of cornea and also found that P2Y2, which is ATP receptor known as expressing microglia, positive cells in peripheral cornea. Stimulation of P2Y2 by P2Y2 agonist showed significant acceleration of corneal nerve repair. We are continuing to study more precise mechanism of corneal nerve repair.
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