Association between the diabetic retinopathy-related gene polymorphisms and the progression of diabetic retinopathy and diabetic macula edema.-A prospective study.

• Project/Area Number: 24791880
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Nakamura Shinko 東京女子医科大学, 医学部, 助教 (70366300)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 糖尿病網膜症 / 遺伝子多型 / 国際情報交換

Outline of Final Research Achievements

①The prospective study: We previously reported that the VEGF(Vascularendothelial growth factor)-2578 polymorphism was associated with diabetic retinopathy. In this prospective study, we examined whether the VEGF-2578 polymorphism was associated with the progression of diabetic retinopathy.②The case-control study: We investigated the association between the ICAM-(Intercellular adhesion molecule-1)gene polymorphisms and the diabetiretinopathy, diabetic macula edema in the case-control study.