Participation of cytokine in the proliferative change in retina of POMGnT1-deficient mice

• Project/Area Number: 24791881
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nippon Medical School
• Principal Investigator: TAKAHASHI Hisatomo 日本医科大学, 医学部, 助教 (10445801)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: POMGnT1 / VEGF / PDGF / HGF

Research Abstract

In retina and vitreous body of POMGnT1-deficient mice which was a model mouse of Muscle-Eye-Brain disease, We analyzed expression of various cytokine and tried elucidation of the mechanism that an astrocytic abnormal increase produced. As a result of immunohistochemistry for VEGF, HGF, and PDGF, it was recognized that the expression of VEGF and PDGF-A in retinal surface and vitreous bodies of POMGnT1-deficient mice was increased.