|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
In retina and vitreous body of POMGnT1-deficient mice which was a model mouse of Muscle-Eye-Brain disease, We analyzed expression of various cytokine and tried elucidation of the mechanism that an astrocytic abnormal increase produced. As a result of immunohistochemistry for VEGF, HGF, and PDGF, it was recognized that the expression of VEGF and PDGF-A in retinal surface and vitreous bodies of POMGnT1-deficient mice was increased.