Molecular targeting in Wnt signal pathway and telomerase for childhood liver tumors
| Project/Area Number |
24791888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
UEDA Yuka 広島大学, 病院, 医科診療医 (70624641)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 癌 / 遺伝子 / シグナル伝達 / マイクロアレイ / トランスレーショナルリサーチ |
|---|
| Research Abstract |
In beta-catenin gene (CTNNB1), deletion and mutation of exon 3 region was detected 107 (50.2%) and 56 (23.2%) of 213 hepatoblastoma cases. The cases whose tumors had high telomerase activity (> 50 RTA) and high TERT expression (> 100) showed poor prognosis. The expression levels of BRG1 were significantly correlated with those of RTA and TERT but not with CTNNB aberrations . The expression levels of the Wnt downstream genes including MYC, MDR-1, CyclinD1, and Survivin were also significantly correlated with those of RTA and TERT. Induced treatment of siRNA against these selected genes into hepatoblastoma cell lines showed growth inhibition. These candidates are considered to be useful for order-made therapy in advanced hepatoblastoma.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT)2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Kurihara S, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T; Japanese Study Group for Pediatric Liver Tumor
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 10
Pages: 1071-1075
DOI
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Peer Reviewed / Open Access
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[Presentation] Survival, surgical respectability, and late effects in the hepatoblastoma patients treated by cisplatin plus pirarubicin(CITA) chemotherapy. (Abstract 10038)2013
Author(s)
Hiyama E, Kamimatsuse A, Onitake Y, Ueda Y, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Oue T
Organizer
ASCO Annual ’ 13 Meeting
Place of Presentation
McComick Place（アメリカ シカゴ）
Related Report
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[Presentation] FURTHER STUDY: IDENTIFICATION OF NEW CANDIDATE GENES IN PROGRESSION OF HEPATOBLASTOMA USING GENOME-WIDE ASSOCIATION STUDY2013
Author(s)
Hiyama E, Ueda Y, Onitake Y, Ida K, Ogura K, Kondo S, Kamijyo T, Watanabe K, Oue T, Hishiki T, Tajiri T, Horie H, Inoue T, Tanaka Y
Organizer
45th Congress of the International Society of Pediatric Oncology
Place of Presentation
Hong Kong Convention and Exhibition Centre(中国 香港）
Related Report
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[Presentation] 高用量シスプラチン療法後に腫瘍全摘を行った門脈浸潤を伴う肝芽腫の一例2013
Author(s)
江藤 昌平, 古江 綾, 千々松 郁枝, 三木 瑞香, 世羅 康彦, 川口 浩史, 中村 和洋, 上田 祐華, 鬼武 美幸, 小倉 薫, 檜山 英三, 小林 正夫
Organizer
第55回日本小児血液・がん学会学術集会
Place of Presentation
ヒルトン福岡シーホーク（福岡市中央区）
Related Report
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[Presentation] 腹腔内Desmoplastic small round cell tumorの1小児例2013
Author(s)
斎藤 聡志, 松本 惇子, 坂田 園子, 千々松 郁枝, 三木 瑞香, 世羅 康彦, 川口 浩史, 中村 和洋, 上田 祐華, 鬼武 美幸, 小倉 薫, 檜山 英三, 小林 正夫
Organizer
第55回日本小児血液・がん学会学術集会
Place of Presentation
ヒルトン福岡シーホーク（福岡市中央区）
Related Report
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[Presentation] DSRCTの1例2012
Author(s)
河島 茉澄, 上田 祐華, 他
Organizer
第53回中国四国小児がん研究会
Place of Presentation
徳島市
Year and Date
2012-04-21
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