Comparison of osteogenic pontential between adipose derived stem cell and ceiling culture derived proliferative adipocyte

• Project/Area Number: 24791896
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Chiba University
• Principal Investigator: ARIKAWA Risa 千葉大学, 医学部附属病院, 医員 (60623600)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨分化 / 脂肪幹細胞 / 脂肪細胞

Research Abstract

Osteoblast and adipocyte locates near in the geneological tree of differentiation, that they bifurcate at the final stage. There is a possibility that treatment of bone defect can be achieved by osteoinduction of cells in fat tissue. However, it is unclear whether adipose derived stem cell or ceiling culture proliferative apipocyte is closer to osteoblast. We clarified that adipose derived stem cell has higher expression of regulators of differentiation into osteoblast than ceiling culture derived proliferative adipocyte. The adipose derived stem cell has higher ability to produce bone matrix in culture for inducing differentiation into osteoblasts than ceiling culture derived proliferative adipocyte.