Development of treatment for primary and secondary lymphedema

• Project/Area Number: 24791898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: HARA Hisako 東京大学, 医学部附属病院, 助教 (50624243)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: リンパ浮腫 / 特発性胸腹水 / 原発性リンパ浮腫 / 二次性リンパ浮腫

Research Abstract

We investigated the collecting lymphatic vessels of the human body histopahologically. The lymphatic vessels were taken during lymphatico-venous anastomosis (LVA) surgery, in which we trim redundant part. We found the changes in lymphatic endothelial cells, smooth muscle cells, and collagen fibers. Also, we examined and treated neonatal lymphatic pleural effusion and ascites, using indocyanine green lymphography and LVA.

Research Products

• [Journal Article] The effect of lymphatico-venous anastomosis for an intractable ulcer at the lower leg in a marked obese patient (2014)
  • Author(s): Mihara M, Hara H, Todokoro T, Seki Y, Iida T, Koshima I, Murai N
  • Journal Title: Microsurgery Volume: 34(1) Pages: 64-7
• [Journal Article] Local anesthesia for lymphaticovenular anastomosis (2014)
  • Author(s): Chan VS, Narushima M, Hara H, Yamamoto T, Mihara M, Iida T, Koshima I
  • Journal Title: Ann Plast Surg Volume: 72(2) Pages: 180-3
• [Journal Article] High-accuracy diagnosis and regional classification of lymphedema using indocyanine green fluorescent lymphography after gynecologic cancer treatment (2014)
  • Author(s): Mihara M, Hayashi Y, Hara H, Iida T, Narushima M, Yamamoto T, Todokoro T, Murai N, Koshima I
  • Journal Title: Ann Plast Surg Volume: 72(2) Pages: 204-8
• [Journal Article] Evaluation of lymphatic dysplasia in patients with congenital pleural effusion and ascites using indocyanine green lymphography. (2014)
  • Author(s): Shibasaki J, Hara H, Mihara M, et al.
  • Journal Title: J Pediatr. Volume: 164(5) Issue: 5 Pages: 1116-1120
  • DOI: 10.1016/j.jpeds.2013.12.052
  • Peer Reviewed
• [Journal Article] High-accuracy diagnosis and regional classification of lymphedema using indocyanine green fluorescent lymphography after gynecologic cancer treatment. (2014)
  • Author(s): Mihara M, Hayashi Y, Hara H, et al.
  • Journal Title: Ann Plast Surg Volume: 72(2) Issue: 2 Pages: 204-8
  • DOI: 10.1097/sap.0b013e3182586b79
  • Peer Reviewed
• [Journal Article] Local anesthesia for lymphaticovenular anastomosis. (2014)
  • Author(s): Chan VS, Narushima M, Hara H, et al.
  • Journal Title: Ann Plast Surg. Volume: 72(2) Issue: 2 Pages: 180-3
  • DOI: 10.1097/sap.0b013e31825b3d1e
  • Peer Reviewed
• [Journal Article] Comparison of indocyanine green lymphographic findings with the conditions of collecting lymphatic vessels of limbs in patients with lymphedema (2013)
  • Author(s): Hara H, Mihara M, Seki Y, Todokoro T, Iida T, Koshima I
  • Journal Title: Plast Reconstr Surg Volume: 132(6) Pages: 1612-8
• [Journal Article] Lymphoedema caused by idiopathic lymphatic thrombus (2013)
  • Author(s): Hara H, Mihara M, Seki Y, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 66(12) Pages: 1780-3
• [Journal Article] Minimally invasive multiple lymphaticovenular anastomosis at the ankle for the prevention of lower leg lymphedema (2013)
  • Author(s): Onoda S, Todokoro T, Hara H, Azuma S, Goto A
  • Journal Title: Microsurgery
• [Journal Article] Treatment of hand lymphedema with free flap transfer and lymphangiogenesis analysis after hand replantation using indocyanine green (ICG) lymphography and histological analysis (2013)
  • Author(s): Mihara M, Hara H, Araki J, Narushima M, Iida T, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 66(11)
• [Journal Article] Predictive Lymphatic Mapping : A Method for Mapping Lymphatic Channels in Patients With Advanced Unilateral Lymphedema Using Indocyanine Green Lymphography (2013)
  • Author(s): Mihara M, Seki Y, Hara H, Iida T, Oka A, Kikuchi K, Narushima M, Haragi M, Furniss D, Hin-Lun L, Mitsui K, Murai N, Koshima I
  • Journal Title: Ann Plast Surg
• [Journal Article] Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis (2013)
  • Author(s): Todokoro T, Furniss D, Oda K, Kawana K, Narushima M, Mihara M, Kikuchi K, Hara H, Yano T, Koshima I
  • Journal Title: Gynecol Oncol Volume: 128(2) Pages: 209-14
• [Journal Article] Pathological steps of cancer-related lymphedema : histological changes in the collecting lymphatic vessels after lymphadenectomy (2013)
  • Author(s): Mihara M, Hara H, Hayashi Y, Narushima M, Yamamoto T, Todokoro T, Iida T, Sawamoto N, Araki J, Kikuchi K, Murai N, Okitsu T, Kisu I, Koshima I
  • Journal Title: PLoS One Volume: 7(7),8(5) Issue: 7 Pages: e41126-e41126
  • DOI: 10.1371/journal.pone.0041126
• [Journal Article] Comparison of indocyanine green lymphographic findings with the conditions of collecting lymphatic vessels of limbs in patients with lymphedema. (2013)
  • Author(s): Hara H, Mihara M, Seki Y, et al.
  • Journal Title: Plastic and Reconstructive Surgery Volume: 132(6) Issue: 6 Pages: 1612-8
  • DOI: 10.1097/prs.0b013e3182a97edc
  • Peer Reviewed
• [Journal Article] Lymphoedema caused by idiopathic lymphatic thrombus. (2013)
  • Author(s): Hara H, Mihara M, Seki Y, et al.
  • Journal Title: J Plast Reconstr Aesthet Surg. Volume: 66(12) Issue: 12 Pages: 1780-3
  • DOI: 10.1016/j.bjps.2013.04.043
  • Peer Reviewed
• [Journal Article] Lymphedema with an idiopathic lymphatic thrombus (2013)
  • Author(s): Hisako Hara M.D., Makoto Mihara M.D., Yukio Seki M.D., et al.
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: in press
  • Peer Reviewed
• [Journal Article] Presence of thoracic duct abnormalities in patients with primary lymphoedema of the extremities (2012)
  • Author(s): Hara H, Mihara M, Okuda I, Hirota A, Narushima M, Iida T, Yamamoto T, Todokoro T, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 65(11)
• [Journal Article] Low-invasive lymphatic surgery and lymphatic imaging for completely healed intractable pudendal lymphorrhea after gynecologic cancer treatment (2012)
  • Author(s): Mihara M, Hara H, Narushima M, Mitsui K, Murai N, Koshima I
  • Journal Title: J Minim Invasive Gynecol Volume: 19(5) Pages: 658-62
• [Journal Article] Antegrade and retrograde lymphatico-venous anastomosis for cancer-related lymphedema with lymphatic valve dysfuction and lymphatic varix (2012)
  • Author(s): Mihara M, Hara H, Iida T, Todokoro T, Yamamoto T, Narushima M, Tashiro K, Murai N, Koshima I
  • Journal Title: Microsurgery Volume: 32(7) Pages: 580-4
• [Journal Article] Scarless lymphatic venous anastomosis for latent and early-stage lymphoedema using indocyanine green lymphography and non-invasive instruments for visualising subcutaneous vein (2012)
  • Author(s): Mihara M, Hara H, Kikuchi K, Yamamoto T, Iida T, Narushima M, Araki J, Murai N, Mitsui K, Gennaro P, Gabriele G, Koshima I
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: 65(11) Pages: 1551-8
• [Journal Article] Presence of thoracic duct abnormalities in patients with primary lymphoedema of the extremities. (2012)
  • Author(s): Hara H, Mihara M, Okuda I, et al.
  • Journal Title: J Plast Reconstr Aesthet Surg Volume: Nov;65(11)
  • Peer Reviewed
• [Journal Article] Idiopathic portal hypertension and lower limb lymphedema. (2012)
  • Author(s): Hara H, Mihara M, Narushima M, et al.
  • Journal Title: Lymphology Volume: Jun;45(2) Pages: 63-70
  • Peer Reviewed
• [Presentation] 新生児の特発性リンパ性胸腹水に対する new strategy (2013)
  • Author(s): 原尚子
  • Organizer: 第54回脈管学会総会
  • Year and Date: 2013-10-10
• [Presentation] 産婦人科領域の腹部リンパ疾患に対する新たな る ア プ ロ ー チ ~ Supermicrosurgeryを用いたリンパ管静脈吻合術~ (2013)
  • Author(s): 原尚子
  • Organizer: 第66回日本産婦人科学会学術講演会
  • Year and Date: 2013-05-12
• [Presentation] ICG 検査で「集合リンパ管の性状」を透視する ~NECST 分類~ (2013)
  • Author(s): 原尚子
  • Organizer: 第56回日本形成外科学会総会・学術集会
  • Year and Date: 2013-04-05
• [Presentation] ICG検査で「集合リンパ管の性状」を透視する ～NECST分類～ (2013)
  • Author(s): 原尚子
  • Organizer: 第56回形成外科学会学術集会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 新生児の特発性胸腹水に対するICG、LVAの応用 (2013)
  • Author(s): 原尚子
  • Organizer: 第56回形成外科学会学術集会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 産婦人科領域の腹部リンパ疾患に対する新たなるアプローチ ～Supermicrosurgeryを用いたリンパ管静脈吻合術～ (2013)
  • Author(s): 原尚子
  • Organizer: 第65回産科婦人科学会学術講演会
  • Place of Presentation: ロイトン札幌
• [Presentation] 婦人科癌術後の下肢リンパ浮腫の早期診断 (2013)
  • Author(s): 原尚子
  • Organizer: 第54回婦人科腫瘍学会
  • Place of Presentation: ホテルグランパシフィック LEDAIBA
• [Presentation] New approach for neonatal lymphatic chylous ascites or pleural effusion (2013)
  • Author(s): Hisako Hara
  • Organizer: 24th congress of International Society of Lymphology
  • Place of Presentation: Rome, Italy
• [Presentation] 新生児の特発性リンパ性胸腹水に対するnew strategy (2013)
  • Author(s): 原尚子
  • Organizer: 第54回脈管学会総会
  • Place of Presentation: ステーションコンファレンス東京
• [Presentation] Diagnostic and therapeutic approaches for neonatal idiopathic peritoneal or pleural effusion (2012)
  • Author(s): Hisako Hara
  • Organizer: Pacific Federation of Societies for Reconstructive Microsurgery
  • Year and Date: 2012-10-07
• [Presentation] 新生児の特発性胸水、腹水に対する 新たなるアプローチ (2012)
  • Author(s): 原 尚子
  • Organizer: 日本臨床外科学会
  • Place of Presentation: 新宿NSビル
• [Presentation] 新生児の特発性胸腹水に対するICG、LVAの応用
  • Author(s): 原尚子
  • Organizer: 周産期循環管理研究会
  • Place of Presentation: 愛仁会看護助産専門学校
• [Presentation] 原発性リンパ浮腫へのあらたなるアプローチ ～MRIによる胸管形態の評価と治療選択～
  • Author(s): 原 尚子
  • Organizer: 日本血管外科学会
  • Place of Presentation: 長野ビッグハット
• [Presentation] 足のむくみを診る ～リンパ浮腫を中心に～
  • Author(s): 原 尚子
  • Organizer: 呉西臨床整形外科医会
  • Place of Presentation: ホテルニューオータニ高岡
  • Invited
• [Presentation] Pathology and therapeutic strategy for lower limb lymphedema and lymphorrhea
  • Author(s): 原 尚子
  • Organizer: Tokyo University Supermicrosurgery Symposium
  • Place of Presentation: 東京大学
• [Presentation] 新生児の特発性胸水、腹水に対する 新たなるアプローチ
  • Author(s): 原 尚子
  • Organizer: 日本小児科学会東京地方会
  • Place of Presentation: 慈恵医科大学
• [Presentation] Diagnostic and therapeutic approaches for neonatal idiopathic peritoneal or pleural effusion
  • Author(s): 原 尚子
  • Organizer: Asian Pacific Federation of Society for Reconstructive Microsurgery
  • Place of Presentation: Singapore
• [Presentation] 新生児の特発性胸水、腹水に対する 新たなるアプローチ
  • Author(s): 原 尚子
  • Organizer: 蛍光Navigation Surgery研究会
  • Place of Presentation: 京都キャンパスプラザ
• [Presentation] 新生児の特発性胸水、腹水に対する 新たなるアプローチ
  • Author(s): 原 尚子
  • Organizer: 日本未熟児・新生児学会
  • Place of Presentation: 熊本
• [Presentation] リンパ浮腫の治療 ～LVAで簡易によい結果を得る方法～
  • Author(s): 原 尚子
  • Organizer: 日本マイクロサージャリー学会
  • Place of Presentation: 北九州国際会議場
  • Invited
• [Book] リンパ管静脈吻合 (2013)
  • Author(s): ORTHOPEDIC SURGERY
  • Publisher: 克誠堂出版
• [Book] ORTHOPLASTIC SURGERY (2013)
  • Author(s): 平瀬雄一、矢島弘嗣
  • Total Pages: 278
  • Publisher: 克誠堂出版