Investigation of human dermal multipotent progenitor cells to utilize for wound treatment
Project/Area Number |
24791902
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Plastic surgery
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 多能性細胞 / 真皮由来幹細胞 / 創傷治癒 / 再生医療 / 真皮幹細胞 / SKPs / 多能性幹細胞 / SKP |
Research Abstract |
Skin-derived precursor (SKP) cells are a valuable resource for wound therapy and regenerative medicine, because they represent multipotent stem cells that differentiate into neural and mesodermal progenies. Previous studies suggest that the stem cell pool decreases with age. We found that human multipotent SKP cells can be efficiently collected from adult cheek/chin skin, even in aged individuals of 70–78 years. The number of spheres obtained from adult facial skin was significantly higher than that of trunk or extremity skin. SKP cells derived from cheek/chin skin exhibited a high ability to differentiate into neural and mesodermal cells relative to those derived from eyelid, trunk, or extremity skin. These results indicate that cheek/chin skin is useful for the recovery of multipotent stem cells for wound therapy and regenerative therapy.
|
Report
(3 results)
Research Products
(4 results)
-
-
[Journal Article] Multipotent stem cells are effectively collected from adult human cheek skin.2012
Author(s)
Yoshikawa, K., Naitoh, M., Kubota, H., Ishiko, T., Aya, R., Yamawaki, S. and Suzuki, S.
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 431
Issue: 1
Pages: 104-110
DOI
Related Report
Peer Reviewed
-
-