| Project/Area Number |
24791907
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka Medical College (2013)
Okayama University (2012) |
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Principal Investigator |
SENO Takaya 大阪医科大学, 医学部, 助教 (90509465)
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| Research Collaborator |
HASEGAWA Kenjiro 岡山大学, 医歯薬学総合研究科・形成外科学教室, 准教授 (90197674)
NARUSE Keiji 岡山大学, 医歯薬学総合研究科・システム生理学教室, 教授 (40252233)
NAGAI Yusuke 岡山大学, 医歯薬学総合研究科・システム生理学教室, 大学院生
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経再生 / 自己集合性ペプチド / 人工神経 |
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| Research Abstract |
We used a new material of self-assembling peputide "Panacea gel" for nerve guidance conduit, and compared to the other prior gel products. We filled the nerve guidance tube lumens with the gels, and transplant into sciatic nerve defect on rat.The neural regeneration in Panacea gel group was well seen, and likely to prior product "PuraMatrix" group, but doesn't catch up to auto nerve graft group. The gel was quickly replaced by original cells, and doesn't inhibit anagenesis. We suggest that self-assembling peputide is usefull material for development of 100% synthetic nerve guidance conduit.
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