Usability of Adipose Tissue in Spinal Cord Injury Treatment
| Project/Area Number |
24791925
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
OHTA Yuki 聖マリアンナ医科大学, 医学部, 助教 (60387066)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂肪組織 / 脊髄損傷 / 細胞治療 |
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| Outline of Final Research Achievements |
Adipose tissue has therapeutic potential for spinal cord injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal cells (ASCs). Intravenous transplantation of ASCs promotes the functional recovery in SCI rats. Interestingly, cytokine-induced neutrophil chemoattractant-1 (CINC-1) showed a transient, but significant increase in the spinal cord tissue and blood of the ASC group. CINC-1 also promoted functional recovery in SCI rats. Glial cell line-derived neurotrophic factor expression was greater in the ASC group than in the CINC-1 group, although both promoted ERK1/2 phosphorylation. Our findings indicate that intravenously transplanted ASCs accumulated in the injured spinal cord, where cytokines such as CINC-1 activated ERK1/2 phosphorylation and induced the downstream production of growth factors, leading to cell regeneration, tissue repair, and functional recovery.
Besides, ASCs could be isolated from frozen tissue, those may be used for research.
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Report
(4 results)
Research Products
(8 results)
