Elucidation of the role of Prostaglandin D synthase in sepsis patients with atherosclerosis and establishment of therapeutic strategy for sepsis

• Project/Area Number: 24791935
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: YAMANE Tetsunobu 滋賀医科大学, 医学部, 助教 (50464194)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 敗血症 / プロスタグランジンD合成酵素 / L-PGDS / 血液浄化法 / PDF / リポカリン型プロスタグランジンD合成酵素

Research Abstract

We examined the serum Lipocalin-type prostaglandin D synthase (L-PGDS) level in critically ill patients admitted to our ICU. The serum L-PGDS level was higher in the sepsis patients compared with the non-sepsis patients. The serum L-PGDS level was correlated with DIC score, numbers of SIRS points, creatinine, lactate, D-dimer, Log IL-6 and Log IL-10. The sever sepsis patients received the blood purification therapy, and the serum L-PGDS level decreased significantly. There was no difference in serum L-PGDS level decrease rate when comparing CHDF therapy and PDF therapy. However, we couldn't treat enough amount of patients with blood purification therapy in this study, we will continue to evaluate the association between the serum L-PGDS level and blood purification therapy.

Research Products

• [Presentation] 敗血症性 DIC の治療の変遷と成績 (2014)
  • Author(s): 辻田靖之, 橋本賢吾, 浜本徹, 山根哲信, 高橋完, 今宿康彦, 松浪薫, 田畑貴久, 松村一弘, 江口豊
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 京都
• [Presentation] 敗血症性DICの治療の変遷と成績 (2014)
  • Author(s): 辻田靖之、橋本賢吾、浜本徹、山根哲信、高橋完、今宿康彦、松浪薫、田畑貴久、松村一弘、江口豊
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 京都
• [Presentation] 重症敗血症性肝障害における持続緩徐式 Plasma Filtration with Dialysis (cPDF)の効果 (2013)
  • Author(s): 江口豊, 今宿康彦, 橋本賢吾, 岸本卓磨, 山根哲信, 浜本徹, 田畑貴久, 辻田靖之
  • Organizer: 第34回日本アフェレシス学会学術大会
  • Place of Presentation: 長野
• [Presentation] Streptococcal toxic shock- like syndrome による多臓器不全に持続緩除式 Plasma Filtration with Dialysis (PDF)が有効であった一例 (2013)
  • Author(s): 橋本賢吾, 白井昌江, 加藤威, 藤本徳毅, 牛塲彩, 岸本卓磨, 大内政嗣, 今宿康彦, 山根哲信, 浜本徹, 藤野和典, 田畑貴久, 松下美季子, 辻田靖之, 松村一弘, 田中俊宏, 江口豊
  • Organizer: 第24回日本急性血液浄化学会学術集会
  • Place of Presentation: 北海道
• [Presentation] Ｓｔｒeptococcal ｔｏｘｉｃ ｓｈｏｃｋ-ｌｉｋｅ ｓｙｎｄｒｏｍｅによる多臓器不全に持続緩除式Ｐｌａｓｍａ Ｆｉｌｔｒａｔｉｏｎ ｗｉｔｈ Ｄｉａlysis（ＰＤＦ）が有効であった一例 (2013)
  • Author(s): 橋本賢吾、白井昌江、加藤威、藤本徳毅、牛塲彩、岸本卓磨、大内政嗣、今宿康彦、山根哲信、浜本徹、藤野和典、田畑貴久、松下美季子、辻田靖之、松村一弘、田中俊宏、江口豊
  • Organizer: 第24回日本急性血液浄化学会学術集会
  • Place of Presentation: 北海道
• [Presentation] 重症敗血症性肝障害における持続緩徐式Ｐｌａｓｍａ Ｆｉｌｔｒａｔｉｏｎ ｗｉｔｈ Ｄｉａlysis（cPDF）の効果 (2013)
  • Author(s): 江口豊、今宿康彦、橋本賢吾、岸本卓磨、山根哲信、浜本徹、田畑貴久、辻田靖之
  • Organizer: 第34回日本アフェレシス学会学術大会
  • Place of Presentation: 長野