| Project/Area Number |
24791935
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 敗血症 / プロスタグランジンD合成酵素 / L-PGDS / 血液浄化法 / PDF / リポカリン型プロスタグランジンD合成酵素 |
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| Research Abstract |
We examined the serum Lipocalin-type prostaglandin D synthase (L-PGDS) level in critically ill patients admitted to our ICU. The serum L-PGDS level was higher in the sepsis patients compared with the non-sepsis patients. The serum L-PGDS level was correlated with DIC score, numbers of SIRS points, creatinine, lactate, D-dimer, Log IL-6 and Log IL-10. The sever sepsis patients received the blood purification therapy, and the serum L-PGDS level decreased significantly. There was no difference in serum L-PGDS level decrease rate when comparing CHDF therapy and PDF therapy. However, we couldn't treat enough amount of patients with blood purification therapy in this study, we will continue to evaluate the association between the serum L-PGDS level and blood purification therapy.
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