| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The mechanisms of crush syndrome in which the local traumatic injuries affect distant organs remain unknown. The purposes of this research were to reveal the involvement of reactive oxygen species (ROS) in systemic inflammation association with distant organ injuries and to evaluate the effects of ETS-GS, a novel vitamin E derivative in a rat model.
The ETS-GS treatment ameliorated the survival in a rat model of crush syndrome. Serum levels of inflammatory cytokines and oxidative stress were significantly decreased in the ETS-GS group compared with those in the control group. Ex vivo imaging confirmed that ETS-GS treatment reduced ROS generation in both the lung and the muscle following crush injury. Administration of ETS-GS could reduce ROS generation, systemic inflammation, and distant organ damage and improve survival in a rat model of crush injury. These results suggest that ROS play an important role in the mechanisms of crush injury.
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