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Establishment of synbiotic therapy in severe sepsis

Research Project

Project/Area Number 24791939
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

YAMADA Tomoki  大阪大学, 医学部附属病院, 医員 (40623434)

Research Collaborator OGURA Hiroshi  大阪大学, 医学系研究科, 准教授 (70301265)
SHIMIZU Kentaro  大阪大学, 医学部附属病院, 助教 (60379203)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsシンバイオティクス / プロバイオティクス / 敗血症 / RCT / 腸内細菌叢 / 短鎖脂肪酸 / 腸管内治療 / SIRS(全身性炎症反応症候群) / 集中治療 / SIRS(全身性炎症症候群)
Outline of Final Research Achievements

The gut is an important target organ for injury after severe insults. We reported that gut microbiota and gut environment deteriorated in patients with severe systemic inflammatory response syndrome (SIRS) and that count of fecal microbiota and concentrations of fecal short-chain fatty acids (SCFAs) in these patients were significantly lower than those in healthy volunteers over a 6-week period. Furthermore, the gut flora was significantly altered in patients with sepsis, especially in non-survivors.
We evaluate if synbiotics therapy can maintain the gut microbiota and environment in patients with severe sepsis. There were significant differences between the synbiotics and no-synbiotics groups by the analysis of changes over time in number of total bacteria, Bifidobacterium, and Lactobacillus, and concentration of acetate and butylate. But there was no significant difference between the two groups about infectious complications and outcome.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Rapid and Sustained Long-Term Decrease of Fecal Short-Chain Fatty Acids in Critically Ill Patients With Systemic Inflammatory Response Syndrome2015

    • Author(s)
      Tomoki Yamada, Kentaro Shimizu, Hiroshi Ogura, Takashi Asahara, Koji Nomoto, Kazuma Yamakawa, Toshimitsu Hamasaki, Yasutaka Nakahori, Mitsuo Ohnishi, Yasuyuki Kuwagata and Takeshi Shimazu
    • Journal Title

      JPEN J Parenter Enteral Nutr

      Volume: 未定 Issue: 5 Pages: 569-577

    • DOI

      10.1177/0148607114529596

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 【ICUにおける早期経腸栄養をめぐって】Critical Careにおけるシンバイオティクス療法2014

    • Author(s)
      山田知輝, 清水健太郎, 小倉裕司, 嶋津岳士
    • Journal Title

      ICUとCCU

      Volume: 38 Pages: 545-554

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 【腸管と免疫・栄養 腸内細菌から疾患を理解する】 全身性炎症反応症候群(SIRS)に対するプロバイオティクス療法の有効性2012

    • Author(s)
      山田 知輝、清水 健太郎、小倉 裕司
    • Journal Title

      臨床栄養

      Volume: 120 Pages: 826-829

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【ICU患者の栄養管理】 重症病態に対する栄養管理の実際 重症感染症2012

    • Author(s)
      山田 知輝、清水 健太郎、中村 洋平、小倉 裕司
    • Journal Title

      栄養-評価と治療

      Volume: 29 Pages: 325-328

    • Related Report
      2012 Research-status Report
  • [Presentation] Synbiotics therapy improves gut dysbiosis in severe sepsis patients; a randomized controlled trial2015

    • Author(s)
      Tomoki Yamada, Kentaro Shimizu, Hiroshi Ogura, Takeyuki Kiguchi, Takashi Asahara, Koji Nomoto, Satoshi Fujimi, Takeshi Shimazu
    • Organizer
      Society of Critical Care Medicine’s 44th Critical Care Congress
    • Place of Presentation
      Phoenix, Arizona USA
    • Year and Date
      2015-01-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] SIRS患者における腸内細菌叢の変化とシンバイオティクス療法2014

    • Author(s)
      山田知輝、清水健太郎、小倉裕司、朝原崇、野本康二、嶋津岳士
    • Organizer
      第27回日本外科感染症学会総会学術集会
    • Place of Presentation
      東京コンファレンスセンター・有明
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腸内環境、腸管機能、耐糖能に注目した経腸栄養管理の取り組みとその成果2014

    • Author(s)
      山田知輝、小倉裕司、清水健太郎、中村洋平、朝原崇、野本康二、嶋津岳士
    • Organizer
      第42回日本救急医学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] SIRS患者における腸内細菌叢・腸内環境の変化とシンバイオティクス療法2014

    • Author(s)
      山田知輝、清水健太郎、小倉裕司、朝原崇、野本康二、吉矢和久、中村洋平、小島将裕、大西光雄、嶋津岳士
    • Organizer
      第51回日本外科代謝栄養学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ALTERED GUT FLORA IN PATIENTS WITH SEPSIS: SURVIVORS VS. NON-SURVIVORS2012

    • Author(s)
      Tomoki Yamada, Kentaro Shimizu, Hiroshi Ogura, et al.
    • Organizer
      35th Annual Conference on Shock
    • Place of Presentation
      マイアミ、USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 臨床研究のseeds;SIRS患者における腸内環境の評価~便中短鎖脂肪酸低下の遷延2012

    • Author(s)
      山田知輝、清水 健太郎、小倉 裕司、朝原 崇、野本 康二、諸冨 正己、鍬方 安行、嶋津 岳士
    • Organizer
      第40回日本救急医学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] SIRS患者における腸内細菌叢の変化とシンバイオティクス療法

    • Author(s)
      山田知輝、清水健太郎、小倉裕司、大西光雄、中村洋平、山川一馬、中川淳一郎、 朝原崇、野本康二、鍬方安行、嶋津岳士
    • Organizer
      第113回  日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] SIRS患者における腸内細菌叢の変化とシンバイオティクス療法

    • Author(s)
      山田知輝、清水健太郎、小倉裕司、朝原崇、野本康二、中村洋平、吉矢和久、山川一馬、大西光雄、嶋津岳士
    • Organizer
      第41回  日本救急医学会総会・学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Remarks] 大阪大学医学部附属病院高度救命救急センター;研究内容の紹介~臨床研究

    • URL

      http://www.osaka-u-taccc.com/research/clinical.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 大阪大学医学部附属病院高度救命救急センター;研究内容の紹介~臨床研究

    • URL

      http://www.osaka-u-taccc.com/research/clinical.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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