The research about efficacy of intensive care for out-of-hospital cardiac arrest patients with cardiac etiology

• Project/Area Number: 24791940
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kansai Medical University (2013-2015); Osaka University (2012)
• Principal Investigator: HAYAKAWA Koichi 関西医科大学, 医学部, 講師 (60403086)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 心原性院外心肺停止 / 集学的治療 / 神経学的予後 / 心肺蘇生 / 予後予測 / 低体温療法

Outline of Final Research Achievements

Accurate prediction of neurological outcome for patients with return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (OHCA) at the time of initial hospital admission will be helpful when considering indications for intensive therapies, such as coronary intervention. We established a multi-center, prospective cohort that included Utstein data in prehospital and treatment contents and data after hospital arrival in 2011. The purpose of this study was to determine the most important indicators of prognosis in patients with ROSC following OHCA and to develop a best outcome prediction model. Multivariate logistic regression analysis was used to identify independent prognostic factors and to develop the best prediction model. We have established highly accurate prediction formula, was presented at an international conference. The results of this research may be useful for family counseling, decision making, and review of treatment in case of OHCA.

Research Products

• [Journal Article] Cohort profile of Comprehensive Registry of In- Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osama, Japan. (2016)
  • Author(s): 1.Yamada T, Kitamura T, Hayakawa K, Yoshiya K, Irisawa T, Abe Y, Ishiro M, Uejima T, Ohishi Y, Kaneda K, Kiguchi T, Kishi M, Kishimoto M, Nakao S, Nishimura T, Hayashi Y, Morooka T, Izawa J, Shimamoto T, Hatakeyama T, Matsuyama T, Kawamura T, Shimazu T, Iwami T.
  • Journal Title: Journal of Intensive Care. Volume: 4(10) Issue: 1 Pages: 1-10
  • DOI: 10.1186/s40560-016-0128-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Prognostic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: Comprehensive Registry of In-Hospital Intensive Care on OHCA Survival (CRITICAL) Study in Osaka, Japan (2016)
  • Author(s): Koichi Hayakawa
  • Organizer: 36th International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Brussels Square Meeting
  • Year and Date: 2016-03-15
  • Int'l Joint Research