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Mechanism and control of inflammation and organ failure in crush syndrome.

Research Project

Project/Area Number 24791941
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

SHIMAZAKI Junya  大阪大学, 医学(系)研究科(研究院), 研究員 (40528767)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsクラッシュ症候群 / 全身性炎症反応症候群 / RAGE / HMGB1 / DAMPs
Research Abstract

Patients with crush injury often present systemic inflammatory response syndrome and fall into multiple organ failure, but the mechanism is still unclear. We focused on RAGE.
(1)In Rat model of crush injury, administration of anti-RAGE antibody reduced inflammatory reaction and improved survival. (2)Patient with SIRS, serum soluble RAGE increased significantly than normal. Soluble RAGE was related to serum HMGB1 or acute DIC score. Expression of RAGE reflect to serum soluble RAGE. In patients with SIRS, RAGE expression may be increased.
These results indicate blocking of RAGE such as anti-RAGE antibody may become a promising novel therapy against crush syndrome or SIRS.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model2013

    • Author(s)
      Yamakawa K, Matsumoto N, Imamura Y, Muroya T, Yamada T, Nakagawa J, Shimazaki J, Ogura H, Kuwagata Y, Shimazu T
    • Journal Title

      PLoS One

      Volume: 8(2)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic involvement of high-mobility group box 1 protein and therapeutic effect of anti-high-mobility group box 1 protein antibody in a rat model of crush injury2012

    • Author(s)
      Shimazaki J, Matsumoto N, Ogura H, Muroya T, Kuwagata Y, Nakagawa J, Yamakawa K, Hosotsubo H, Imamura Y, Shimazu T
    • Journal Title

      Shock

      Volume: 37(6) Pages: 634-638

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic involvement of HMGB1 and therapeutic effect of anti-HMGB1 antibody in a rat model of crush injury2012

    • Author(s)
      Shimazaki J., Matsumoto N., Ogura H., Muroya T., Kuwagata Y., Nakagawa J., Yamakawa K., Hosotsubo H., Imamura Y., and Shimazu T.
    • Journal Title

      Shock

      Volume: 37 Issue: 6 Pages: 634-638

    • DOI

      10.1097/shk.0b013e31824ed6b7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] SIRS 病態の解明とその制御 : 細胞機能, 免疫機能からみたアプローチ2014

    • Author(s)
      小倉裕司
    • Organizer
      第41回集中治療学会
    • Place of Presentation
      京都
    • Year and Date
      2014-02-27
    • Related Report
      2013 Final Research Report
  • [Presentation] クラッシュ症候群における臓器障害進行のメカニズム解明と制御2012

    • Author(s)
      島崎淳也
    • Organizer
      第112回外科学会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] クラッシュ症候群における臓器障害進行のメカニズム解明と制御2012

    • Author(s)
      島崎淳也、松本直也、小倉裕司、中川淳一郎 山川一馬、鍬方安行、嶋津岳士
    • Organizer
      第112回日本外科学会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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