| Project/Area Number |
24791951
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | コカイン / 高体温 / 非定型抗精神病薬 / リスペリドン / モノアミン / DA / NA / 5-HT |
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| Research Abstract |
Cocaine, an illegal psychostimulant, is widely used globally. Hyperthermia is closely related to cocaine lethality effect. Cocaine has been reported to induce hyperthermia mainly by causing DA release. We hypothesized that risperidone could suppress cocaine-induced hyperthermia. Cocaine s.c. injection induced hyperthermia in rats, which was significantly suppressed by the injected risperidone. D1 and 5-HT2A receptor antagonists prevent cocaine-induced hyperthermia; thus,risperidone`s ability to prevent cocaine-induced hyperthermia might be mainly attributable to its D1 and 5-HT2A receptor antagonism.In the microdialysis study, we found that i.p. cocaine administration increased DA, 5-HT, and NA levels in the anterior hypothalamus, and that risperidone pretreatment significantly suppressed the cocaine-induced increase in DA levels.
Our results indicate that risperidone is a potentially useful drug for treating cocaine-induced acute hyperthermia in humans.
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