Study of tooth morphogenesis from the aspect of local regulation of phosphate metabolism: An epigenomic approach.
| Project/Area Number |
24791962
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エピジェネティクス / 歯胚 / リン代謝 |
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| Research Abstract |
We have performed histological and molecular experiment to uncover the distribution of epigenetic modifications, especially DNA methylation and hydroxymethylation, and related factors during mouse amelogenesis. The global increase of 5-hydroxymethylcytosine levels was observed when the ameloblast cells enter into secretory stage; then onset of differentiation into secretory stage, the formation of chromocenter was observed. Also, Dnmt1 mRNA and protein expression showed highest levels in immature dental epithelial cells, with decreasing levels at later stages of development. These results suggest that Dnmt1 may sustain the maintenance of undifferentiation status of dental epithelial cells.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] Imaging Mass Spectrometry-based Molecular Histology of Bone Shows the Implication of MEPE-ASARM for the Klotho-Deficient Phenotype.2013
Author(s)
Fujino Y, Minamizaki T, Sakurai K, Irie Y, Yoshioka H, Takei Y, Kozai K, Okada M, Yoshiko Y.
Organizer
The American Society for Bone and Mineral Research 2013 Annual Meeting
Place of Presentation
Baltimore, MD, USA
Related Report
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