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Craniocervical bone innervations in relation to bone metabolism and immune system

Research Project

Project/Area Number 24791972
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

IMURA Kosuke  日本歯科大学, 生命歯学部, 講師 (10415086)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords末梢神経 / 骨 / 骨髄 / 骨代謝 / CGRP / 魚類 / 咽頭顎 / 神経終末 / 骨免疫学 / 表現型可塑性
Research Abstract

Recent studies have discussed that harmonization between bone metabolism and immune system. While, bone innervation has been discussed about contribution to bone metabolism. I have investigated the innervations of craniocervical bones, in the bone marrow and periosteum, by means of immunohistochemistry for detection of calcitonin gene related peptide (CGRP) and vesicular glutamate transporter expressions. In these, CGRP positive nerve terminals may interact with CGRP receptor expressed osteoclast and/or immunocompetent cells. And also, I have analyzed teleost pharyngeal jaw bone innervation (PJi) as a model animal for revealing bone-innervating neural pathway. Existence of the PJi was demonstrated clearly.Traceable peripheral nerves from bone-periphery to brain in an individual was an advantage for analyzing the neural system.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 Other

All Presentation (6 results)

  • [Presentation] 下咽頭顎骨(Lower Pharyngeal Jaw)内の神経分布について2014

    • Author(s)
      井村 幸介, 吉本 正美, 山本 直之, 佐藤巌
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(栃木県)
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨を支配する末梢 : 咽頭顎骨(Lower Pharyngeal Jaw)内の神経分布についてObservation of nerve distributions in the pharyngeal jaw2013

    • Author(s)
      井村 幸介, 吉本 正美, 山本 直之
    • Organizer
      第10回水生動物の行動と神経系シンポジウム
    • Place of Presentation
      鹿児島大学(鹿児島県)
    • Year and Date
      2013-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 咽頭顎骨(Pharyngeal jaw)における神経分布について2013

    • Author(s)
      井村 幸介, 吉本 正美, 山本 直之
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場(香川県)
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 咽頭顎骨(Pharyngeal jaw)における神経分布について2013

    • Author(s)
      井村幸介、吉本正美、山本直之
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県高松市 サンポートホール高松・かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 下咽頭顎骨(Lower Pharyngeal Jaw)内の神経分布について

    • Author(s)
      井村幸介、吉本正美、佐藤巌、山本直之
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(栃木県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨を支配する末梢神経:咽頭顎骨(Pharyngeal jaw)内の神経分布についてObservation of nerve distributions in the pharyngeal jaw

    • Author(s)
      井村幸介、吉本正美、山本直之
    • Organizer
      第10回水生動物の行動と神経系シンポジウム
    • Place of Presentation
      鹿児島大学(鹿児島県)
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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