| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of our research is to clarify whether fibrocytes participate in fibrous adhesion in temporomandibular joint (TMJ). For in vivo imaging of fibrocytes homing to TMJ tissues, we isolated adhesive mononuclear cells containing fibrocytes from bone marrows of fluorescent transgenic mice and administered monosodium iodoacetate into the upper compartment of mouse TMJ in order to generate a mouse model of TMJ osteoarthritis. Moreover, we gained fibroblast-like cells from TMJ tissues and showed the possibility that fibrocytes were homed to inflamed TMJ sites by migratory factors secreted from TMJ tissues stimulated with inflammatory cytokines.
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