| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Articular cartilage has poor ability to regenerate and repair, and thereby proceed toward osteoarthritis. The superficial layer (SFL) in articular cartilage has received much attention as an initial site of cartilage degeneration, however, the exact regulation of SFL function remain largely unclear. We have found that Wnt/β-catenin signaling is critical for maintenance of SFL in articular cartilage using the loss- and gain-of-function approaches of β-catenin. Rac-1, one of the small GTPase has been shown to regulate β-catenin signaling pathway. In this study, we tested whether β-catenin and Rac-1 signaling pathways have a crosstalk in regulation of SFL function in articular cartilage. The results from this study suggest that Rac-1 and Wnt/β-catenin signaling could cooperatively regulate SFL proliferation and function.
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