The study of the signaling cross talks between Wnt/beta-catenin and Rac1 signaling in Regulation of Maintenance and Function of Superficial Cell Layer in Articular Cartilage
Project/Area Number |
24791983
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Showa University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 関節軟骨 / 再生医学 / 細胞・組織 / 遺伝子 / 軟骨 / シグナル伝達 / Wnt/β-catenin |
Outline of Final Research Achievements |
Articular cartilage has poor ability to regenerate and repair, and thereby proceed toward osteoarthritis. The superficial layer (SFL) in articular cartilage has received much attention as an initial site of cartilage degeneration, however, the exact regulation of SFL function remain largely unclear. We have found that Wnt/β-catenin signaling is critical for maintenance of SFL in articular cartilage using the loss- and gain-of-function approaches of β-catenin. Rac-1, one of the small GTPase has been shown to regulate β-catenin signaling pathway. In this study, we tested whether β-catenin and Rac-1 signaling pathways have a crosstalk in regulation of SFL function in articular cartilage. The results from this study suggest that Rac-1 and Wnt/β-catenin signaling could cooperatively regulate SFL proliferation and function.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Plasmablastic lymphoma of the maxillary sinus with intraoral manifestation caused by direct alveolar bone infiltration in an HIV-negative patient.2014
Author(s)
Yasuhara R, Irie; T, Shiozawa E, Yamochi T, Tanaka J, Kohno Y, Fujikura M, Kimura Y, Hanazawa T, Seki K, Sano T, Shirota T, Kushima M, Takimoto M, Mishima K.
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Journal Title
Pathol Int.
Volume: 64(11)
Issue: 11
Pages: 588-90
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
Author(s)
Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
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Journal Title
J.Biol.Chem.
Volume: 289
Issue: 22
Pages: 1-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice.2013
Author(s)
Cantley L, Saunders C, Guttenberg M, Ohta Y, Yasuhara R, Kondo N, Tung W, Candela E. M, Sgariglia F, Asai S, Zhang X, Qin L, Hecht T. J, Chen D, Toyosawa S, Dormans P. J, Iwamoto M, Pacifici M and Enomoto-Iwamoto M.
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Journal Title
Am J Pathol.
Volume: 182(3)
Issue: 3
Pages: 912-27
DOI
Related Report
Peer Reviewed
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[Journal Article] Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma.2013
Author(s)
Hayashi S, Tanaka J, Okada S, Isobe T, Yamamoto G, Yasuhara R, Irie T, Akiyama C, Kohno Y, Tachikawa T, Mishima K.
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Journal Title
Exp Cell Res
Volume: 319
Issue: 8
Pages: 1220-1228
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of side population cells restores the function of damaged exocrine glands through clusterin2012
Author(s)
Mishima K., Inoue H., Nishiyama T., Mabuchi Y., Amano Y., Ide F., Matsui M., Yamada H., Yamamoto G., Tanaka J., Yasuhara R., Sakurai T., Lee M., Chiba K., Sumimoto H., Kawakami Y., Matsuzaki Y., Tsubota K., Saito I
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Journal Title
Stem Cells
Volume: 30
Issue: 9
Pages: 1925-37
DOI
Related Report
Peer Reviewed
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