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The understanding of the neural circuits in the brainstem involved in jaw movement using laser photolysis

Research Project

Project/Area Number 24791984
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

NAKAMURA Shiro  昭和大学, 歯学部, 助教 (60384187)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords顎運動 / 三叉神経運動核 / プレモーターニューロン / ケージド化合物 / パッチクランプ / 脳幹スライス標本 / 顎筋運動ニューロン / 発育変化 / caged -glutamate / 三叉神経運動ニューロン / シナプス伝達 / ケージドグルタミン酸
Research Abstract

We revealed that the neural circuits involved in jaw movement differed between jaw-closing and jaw-opening muscles and changed with postnatal development, using the systematic laser photostimulation method. The outcomes of this study provide information of understandings of mechanisms that are responsible for development and maintenance of orofacial functions and physical-psychic activities. Furthermore, our basic data obtained from this study are important for development of treatments of masticatory disorders and rehabilitation of masticatory functions.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (20 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Electrophysiological and morphological properties of rat supratrigeminal premotor neurons targeting the trigeminal motor nucleus2014

    • Author(s)
      Nakamura S, Nakayama K, Mochizuki A, Sato F, Haque T, Yoshida A, Inoue T
    • Journal Title

      J Neurophysiol

      Volume: 111(9) Pages: 1770-1782

    • Related Report
      2013 Final Research Report
  • [Journal Article] Electrophysiological and morphological properties of rat supratrigeminal premotor neurons targeting the trigeminal motor nucleus2014

    • Author(s)
      Nakamura S, Nakayama K, Mochizuki A, Sato F, Haque T, Yoshida A, Inoue T
    • Journal Title

      J Neurophysiol

      Volume: in press Issue: 9 Pages: 1770-1782

    • DOI

      10.1152/jn.00276.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal changes in the repetitive firing properties of rat jaw-closing motoneurons2013

    • Author(s)
      Inoue T, Yamaoka A, Hironaka S, Nakamura S, Nakayama K, Mochizuki A, Mukai Y, Itabashi K
    • Journal Title

      J Jpn Soc Stomatognath Funct

      Volume: 19 (2) Pages: 137-144

    • NAID

      130004839376

    • Related Report
      2013 Final Research Report
  • [Journal Article] Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro2013

    • Author(s)
      Ihara Y, Nakayama K, Nakamura S, Mochizuki A, Takahashi K, Inoue T
    • Journal Title

      Neurosci Res

      Volume: 75(2) Pages: 138-149

    • Related Report
      2013 Final Research Report
  • [Journal Article] Postnatal changes in the repetitive firing properties of rat jaw-closing motoneurons2013

    • Author(s)
      Inoue T, Yamaoka A, Hironaka S, Nakamura S, Nakayama K, Mochizuki A, Mukai Y, Itabashi K.
    • Journal Title

      The Journal of Japanese Society of Stomatognathic Function

      Volume: 19 Pages: 137-144

    • NAID

      130004839376

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro.2013

    • Author(s)
      Ihara Y, Nakayama K, Nakamura S, Mochizuki A, Takahashi K, Inoue T.
    • Journal Title

      Nerosci Res

      Volume: 75(2) Issue: 2 Pages: 138-49

    • DOI

      10.1016/j.neures.2012.11.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergent premotoneuronal inputs to single trigeminal motoneurons2012

    • Author(s)
      Nonaka M, Nishimura A, Nakamura S, Nakayama K, Mochizuki A, Iijima T, Inoue T
    • Journal Title

      J Dent Res

      Volume: 91 Pages: 888-893

    • Related Report
      2013 Final Research Report
  • [Journal Article] Convergent premotoneuronal inputs to single trigeminal motoneurons.2012

    • Author(s)
      Nonaka M, Nishimura A, Nakamura S, Nakayama K, Mochizuki A, Iijima T and Inoue T.
    • Journal Title

      J Dent Res

      Volume: 91(9) Issue: 9 Pages: 888-893

    • DOI

      10.1177/0022034512453724

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of histamine on neurotransmission from the mesencephalic trigeminal nucleus to trigeminal motoneurons in rats2013

    • Author(s)
      Gemba C, Nakayama K, Nakamura S, Mochizuki A, Inoue M, Inoue T
    • Organizer
      Society for Neuroscience 43rd annual meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 三叉神経上核プレモーターニューロンの形態学的および生理学的特性2013

    • Author(s)
      中村史朗, 中山希世美, 望月文子, 吉田篤, 井上富雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Postnatal development of convergent premotoneuronal inputs to single trigeminal motoneurons2013

    • Author(s)
      Nakamura S, Matsuda K, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Inoue T
    • Organizer
      2nd Meeting of the International Association for Dental Research
    • Place of Presentation
      Asia Pacific Region, Bangkok
    • Year and Date
      2013-08-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Neural mechanisms controlling jaw and tongue movements. Symposia2013

    • Author(s)
      Inoue T, Nonaka M, Ihara Y, Nakamura S, Nakayama K, Yazawa I, Mochizuki A
    • Organizer
      Neural control of feeding behaviors
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス咬筋活動に対する睡眠ー覚醒の影響2013

    • Author(s)
      片山慶祐 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗, 中山希世美, 矢澤 格, 馬場一美, 井上富雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウスの咬筋および頸筋活動に対する睡眠―覚醒パターンの影響2013

    • Author(s)
      片山慶祐 望月文子, 加藤隆史, 池田美菜子,野川泰葉, 中村史朗, 中山希世美, 矢澤 格, 馬場一美, 井上富雄
    • Organizer
      第51回日本顎口腔機能学会学術大会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Masseter muscle activity during awake state, non-REM sleep and REM sleep in mice2013

    • Author(s)
      Katayama K, Mochizuki A, Kato T, Ikeda M, Nakayama K, Nakamura S, Yazawa I, Baba K, Inoue T
    • Organizer
      Society for Neuroscience 43rd annual meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三叉神経上核プレモーターニューロンの形態学的および生理学的特性2013

    • Author(s)
      中村史朗、中山希世美、望月文子、吉田篤、井上富雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三叉神経運動ニューロン樹状突起の能動的特性2013

    • Author(s)
      中井健人、中村史朗、望月文子、中山希世美、矢澤格、井上富雄
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dendritic signal processing in the trigeminal motoneurons2013

    • Author(s)
      Nakai K, Nakamura S, Mochizuki A, Nakayama K, Inoue T
    • Organizer
      2nd Meeting of the International Association for Dental Research – Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Presentation] Postnatal development of convergent premotoneuronal inputs to single trigeminal motoneurons2013

    • Author(s)
      Nakamura S, Matsuda K, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Inoue T
    • Organizer
      2nd Meeting of the International Association for Dental Research – Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三叉神経運動ニューロン樹状突起における情報処理機構2012

    • Author(s)
      中村史朗, 望月文子, 中山希世美, 井上富雄
    • Organizer
      日本顎口腔機能学会第49回学術大会
    • Place of Presentation
      北九州
    • Year and Date
      2012-10-21
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 三叉神経運動核周囲領域からの三叉神経運動ニューロンに対する収束性入力2012

    • Author(s)
      野中睦美, 松田啓資, 中村史朗, 中山希世美, 望月文子, 横山敦郎, 飯島毅彦, 井上富雄
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Convergent inputs to single trigeminal motoneurons from the premotor neurons which were located in the regions surrounding the trigeminal motor nucleus in rats2012

    • Author(s)
      Nakamura S, Nonaka M, Matsuda K, Nakayama K, Mochizuki A, Iijima T, Inoue T
    • Organizer
      NANOSYMPOSIUM; Oral movements; Theme D: Sensory and Motor Systems, Soc Neurosci abstr 14.10, Neuroscience
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Final Research Report
  • [Presentation] Coordination of NMDA-induced suckling-like rhythmic activity in the trigeminal and hypoglossal nerves of In vitro brain preparations from newborn mice2012

    • Author(s)
      Inoue T, Nakayama K, Ihara Y, Nakamura S, Mochizuki A, Takahashi K
    • Organizer
      NANOSYMPOSIUM; Oral movements; Theme D: Sensory and Motor Systems, Soc Neurosci abstr 14.01, Neuroscience 2012
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Final Research Report
  • [Presentation] Convergent inputs to single trigeminal motoneurons from the premotor neurons which were located in the regions surrounding the trigeminal motor nucleus in rats.2012

    • Author(s)
      Nakamura S, Nonaka M, Matsuda K, Nakayama K, Mochizuki A, Iijima T, Inoue T
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Coordination of NMDA-induced suckling-like rhythmic activity in the trigeminal and hypoglossal nerves of In vitro brain preparations from newborn mice.2012

    • Author(s)
      Inoue T, Nakayama K, Ihara Y, Nakamura S, Mochizuki A, Takahashi K
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 三叉神経運動核周囲領域に存在するプレモーターニューロンの形態学的および電気生理学的特性2012

    • Author(s)
      中村史朗、中山希世美、望月文子、吉田篤、井上富雄
    • Organizer
      第6回Motor Control研究会
    • Place of Presentation
      岡崎
    • Related Report
      2012 Research-status Report
  • [Presentation] 三叉神経運動ニューロンに対するプレモーターニューロンからの入力様式の発育変化2012

    • Author(s)
      松田啓資、中村史朗、横山敦郎、野中睦美、井上富雄
    • Organizer
      日本補綴歯科学会第121回学術大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 新生マウスにおけるNMDA 誘発リズム活動の三叉神経,舌下神経間での関係2012

    • Author(s)
      伊原良明、中山希世美、中村史朗、望月文子、井上富雄
    • Organizer
      日本顎口腔機能学会第48回学術大会
    • Place of Presentation
      長野
    • Related Report
      2012 Research-status Report
  • [Remarks] 昭和大学歯学部口腔生理学講座

    • URL

      http://www10.showa-u.ac.jp/~oralphys/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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