Immunological analysis of metal allergy by original animal model

• Project/Area Number: 24791996
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: SATO Naoki 東北大学, 加齢医学研究所, 非常勤講師 (50625043)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: アレルギー・ぜんそく / 金属 / アレルギー / 炎症 / 細胞

Outline of Final Research Achievements

Metal allergy is categorized in the delayed allergy, because the emerging symptoms to wait at least 24 hours after contact with the metal. Therefore, it has been difficult to determine the cause of metal allergy and the study of metal allergy has not been progressing. Recently, we have originally developed new metal allergy animal models by inoculating the bacterial component and a metal solution of bacteria in mice. Since the animal model is very similar to the diseases of human metal allergies, we performed the pathological analysis by using this model. We found that the metal-specific T cells are present and the metal-specific T cells are pathogenic T cells of metal allergy. The pathogenic T cells are activated by palladium inoculation.

Research Products

• [Journal Article] NKG2D+ IFN-γ+ CD8+ T cells are responsible for palladium allergy. (2014)
  • Author(s): Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.
  • Journal Title: PLoS One. Volume: 9 Issue: 2 Pages: 1-12
  • DOI: 10.1371/journal.pone.0086810
  • Peer Reviewed / Open Access
• [Journal Article] 金属アレルギー研究：動物モデルによる免疫学的解析 (2013)
  • Author(s): 1. 川野光子、遠藤実里、佐藤直毅、鈴木隆二、小笠原康悦
  • Journal Title: 実験医学 Volume: 31 (17) Pages: 137-142
• [Journal Article] 免疫抑制にはたらくドレスNK細胞の発見 (2013)
  • Author(s): 2. 橋元亘, 中村恭平, 遠藤実里, 島田栄理遣, 小笠原康悦, 中山勝文, 佐藤直毅, 樋口繁仁
  • Journal Title: 炎症と免疫 Volume: 21(4) Pages: 297-304
• [Book] 炎症と免疫 (2013)
  • Author(s): 橋元亘、中村恭平、遠藤実里、島田栄理遣、小笠原康悦、中山勝文、佐藤直毅、樋口繁仁
  • Publisher: 先端医学社