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Functional analysis of oral cancer stem cell related gene, SPRR1B

Research Project

Project/Area Number 24792005
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionSapporo Medical University

Principal Investigator

MICHIFURI Yoshitaka  札幌医科大学, 医学部, 研究員 (00457722)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔がん / がん幹細胞 / SPRR1B / 口腔扁平上皮癌
Outline of Final Research Achievements

We isolated oral cancer stem-like cells(CSCs)/cancer-initiating cells(CICs) by aldefluor assay. A cDNA microarray analysis revealed that SPRR1B is preferentially expressed in oral CSCs/CICs. Gene overexpression and gene knockdown experiments revearled that SPRR1B has a role in the cell growth of oral CSCs/CICs by activation of RAS signal. These observations indicate that SPRR1B might be a promising molecular target for treatment resistant oral CSCs/CICs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013

    • Author(s)
      Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 439 Issue: 1 Pages: 96-102

    • DOI

      10.1016/j.bbrc.2013.08.021

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Highexpression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cellcarcinomas correlates to lymph node metastasis.2013

    • Author(s)
      Michifuri Y, Hirohashi Y, Torigoe T,Miyazaki A, Kobayashi J, Sasaki T, FujinoJ, Asanuma H, Tamura Y, Nakamori K, Hasegawa T, Hiratsuka H, Sato N.
    • Journal Title

      Pathol Int.

      Volume: 62(10) Issue: 10 Pages: 684-9

    • DOI

      10.1111/j.1440-1827.2012.02851.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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