Functional analysis of oral cancer stem cell related gene, SPRR1B
Project/Area Number |
24792005
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Sapporo Medical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 口腔がん / がん幹細胞 / SPRR1B / 口腔扁平上皮癌 |
Outline of Final Research Achievements |
We isolated oral cancer stem-like cells(CSCs)/cancer-initiating cells(CICs) by aldefluor assay. A cDNA microarray analysis revealed that SPRR1B is preferentially expressed in oral CSCs/CICs. Gene overexpression and gene knockdown experiments revearled that SPRR1B has a role in the cell growth of oral CSCs/CICs by activation of RAS signal. These observations indicate that SPRR1B might be a promising molecular target for treatment resistant oral CSCs/CICs.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.2013
Author(s)
Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N.
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Journal Title
Biochem Biophys Res Commun
Volume: 439
Issue: 1
Pages: 96-102
DOI
Related Report
Peer Reviewed
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[Journal Article] Highexpression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cellcarcinomas correlates to lymph node metastasis.2013
Author(s)
Michifuri Y, Hirohashi Y, Torigoe T,Miyazaki A, Kobayashi J, Sasaki T, FujinoJ, Asanuma H, Tamura Y, Nakamori K, Hasegawa T, Hiratsuka H, Sato N.
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Journal Title
Pathol Int.
Volume: 62(10)
Issue: 10
Pages: 684-9
DOI
Related Report
Peer Reviewed