Ectopic expression of HMGA2 in oral carcinomas and tumor progression

• Project/Area Number: 24792012
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The Nippon Dental University
• Principal Investigator: MAEDA Genta 日本歯科大学, 生命歯学部, 助教 (80434140)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 癌 / EMT / HMGA2 / 口腔扁平上皮癌

Research Abstract

HMGA2 is expressed typically in the mesenchymal cell before its differentiation, but it is also expressed in tumors of epithelium. Ectopic expression of High mobility group-A2 (HMGA2) in epithelial tumor cell is a deriver of mesenchymal transition (EMT), which has been implicated in the achievement of metastatic characters in tumor cells. Those date demonstrate that HMGA2 combined the Zic1 promoter site and controlled target gene expression in oral tumor cells, thereby inducing invasion and metastasis of human epithelial cancers.

Research Products

• [Journal Article] Concomitant loss of p120-catenin and β-c atenin membrane expression and oral carcino ma progression with E-cadherin reduction (2013)
  • Author(s): Sasa ya K, Sudo H, Maeda G, Kawashiri S, Imai K
  • Journal Title: PLoS One Volume: 6 Pages: 8-8
• [Journal Article] Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction (2013)
  • Author(s): Sasaya K, Sudo H, Maeda G, Kawashiri S, Imai K
  • Journal Title: PLoS One Volume: Aug 6;8(8) Issue: 8 Pages: 6-8
  • DOI: 10.1371/journal.pone.0069777
  • Peer Reviewed
• [Journal Article] Mutational analysis of HRAS and KRAS genes in oral carcinoma cell lines (2012)
  • Author(s): Maemoto S, Yumoto M, Ibata M, Torizuka S, Ozawa N, Tatsumi S, Hashido M, Morikawa M, Ma eda G, Imai K
  • Journal Title: Odontology Volume: 100(2) Pages: 149-55
• [Journal Article] Pericyte depletion results in hypoxia-assoc iated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway (2012)
  • Author(s): Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R
  • Journal Title: Canc er Cell Volume: 21(1) Pages: 66-81
• [Journal Article] Progression of oral squamous cell carcino ma accompanied with reduced E-cadherin exp ression but not cadherin switch (2012)
  • Author(s): Hashimoto T, Soeno Y, Maeda G, Taya Y, Aoba T, Nasu M, Kawashiri S, Imai K
  • Journal Title: PLoS One Volume: 7
• [Presentation] 日本歯科基礎医学界 (2012)
  • Author(s): 前田 元太
  • Organizer: 血管周皮細胞欠失による上皮間葉移行と癌転移はMet シグナルにより制御される.
  • Place of Presentation: 奥羽大学
  • Year and Date: 2012-09-15