| Project/Area Number |
24792012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
MAEDA Genta 日本歯科大学, 生命歯学部, 助教 (80434140)
|
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
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| Keywords | 癌 / EMT / HMGA2 / 口腔扁平上皮癌 |
|---|
| Research Abstract |
HMGA2 is expressed typically in the mesenchymal cell before its differentiation, but it is also expressed in tumors of epithelium. Ectopic expression of High mobility group-A2 (HMGA2) in epithelial tumor cell is a deriver of mesenchymal transition (EMT), which has been implicated in the achievement of metastatic characters in tumor cells. Those date demonstrate that HMGA2 combined the Zic1 promoter site and controlled target gene expression in oral tumor cells, thereby inducing invasion and metastasis of human epithelial cancers.
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