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Effects of ions released from dental cements on osteoblast-like cells

Research Project

Project/Area Number 24792023
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

KIBA Wakako  大阪大学, 歯学研究科(研究院), 招聘教員 (10523087)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords保存修復学 / 歯科用修復材料 / 骨芽細胞
Research Abstract

To examine each of BO33-, Sr2+, Al3+, Na+, SiO32-, and F-, we succeed to make solutions with same counter ions such as H3BO3, Sr(NO3)2, Al(NO3)3, Na2SiO3, and NaF at the neutral pH. MC3T3-E1 cells were seeded and each solution was added. Cell proliferation was examined by MTT assay. Significant increase in the cell number was obtained by Sr(NO3)2. Culture with H3BO3 for 3 days and NaF demonstrated inhibition of cell proliferation in a dose-dependent manner. MC3T3-E1 cells proliferate well in the presence of Sr(NO3)2, indicating the positive effects of Sr2+ ion on osteoblasts. On the contrary, BO33- and F- appear to have negative influences on osteoblastic proliferation.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (2 results)

  • [Journal Article] エビデンスに基づく根面う蝕の治療方針2014

    • Author(s)
      騎馬和歌子, 今里聡
    • Journal Title

      日本歯科評論

      Volume: 74 Pages: 37-43

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Mechanism of detoxification of the cationic antibacterial monomer 12-methacryloyloxydodecylpyridiniumbrom ide (MDPB) by N-acetyl cysteine2013

    • Author(s)
      Ma S, Imazato S, Takahashi Y, Kiba W, Takeda K, Izutani N, Kitagawa H, Chen J
    • Journal Title

      Dent Mater

      Volume: 29 Pages: 1219-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chen JH. Mechanism of detoxification of the cationic antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) by N-acetyl cysteine2013

    • Author(s)
      Ma S, Imazato S, Takahashi Y, Kiba W, Takeda K, Izutani N, Kitagawa H
    • Journal Title

      Dent Mater

      Volume: 29, 12 Issue: 12 Pages: 1219-27

    • DOI

      10.1016/j.dental.2013.09.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] S-PRG フィラーから溶出する各イオンの抗菌性への関与2013

    • Author(s)
      三木彩希, 騎馬和歌子, 北川蘭奈, 林 美加子, 今里 聡
    • Organizer
      第62回日本歯科理工学会
    • Place of Presentation
      新潟市
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of ions released from S-PRG filler on osteoblast-like cells2013

    • Author(s)
      W. KIBA, S. MIKI, S. IMAZATO
    • Organizer
      IADR-APR
    • Place of Presentation
      Bangkok, Thai
    • Year and Date
      2013-08-19
    • Related Report
      2013 Final Research Report
  • [Presentation] マルチイオン徐放性S-PRG フィラー含有試作セメントへの骨芽細胞様細胞への付着性騎馬和歌子2013

    • Author(s)
      三木彩希, 今里聡
    • Organizer
      第61回歯科理工学会
    • Place of Presentation
      東京都 タワーホール舟堀
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] マルチイオン徐放性S-PRGフィラー含有試作セメントへの骨芽細胞様細胞の付着性2013

    • Author(s)
      騎馬和歌子,三木彩希,今里 聡
    • Organizer
      第61回歯科理工学会
    • Place of Presentation
      舟堀、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of ions released from S-PRG filler on osteoblast-like cells2013

    • Author(s)
      W. KIBA, S. MIKI, S. IMAZATO
    • Organizer
      IADR-APR
    • Place of Presentation
      バンコク、タイ
    • Related Report
      2013 Annual Research Report
  • [Presentation] S-PRGフィラーから溶出する各イオンの抗菌性への関与2013

    • Author(s)
      三木彩季,騎馬和歌子,北川蘭奈,林美加子,今里 聡
    • Organizer
      第62回日本歯科理工学会
    • Place of Presentation
      新潟
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evaluation of osteoblast-like cells proliferation on S-PRG filler-containing cement

    • Author(s)
      W. KIBA, S. IMAZATO, S. MIKI, M. HAYASHI
    • Organizer
      91th IADR/AADR/CADR General Session & Exhibition
    • Place of Presentation
      Seattle, WA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] マルチイオン徐放性S-PRGフィラー含有試作セメントへの骨芽細胞様細胞の付着性

    • Author(s)
      騎馬和歌子,三木彩希,今里 聡
    • Organizer
      第61回日本歯科理工学会
    • Place of Presentation
      舟堀、東京
    • Related Report
      2012 Research-status Report
  • [Book] デンタルカリエス 原著第2版 その病態と臨床マネージメント2013

    • Author(s)
      高橋信博・恵比須繁之 監訳 山口幹代 青葉孝昭 景山正登 大野純一 岩見行晃 木本敦稲葉大輔 佐野哲也 佐藤拓一 渡部茂 渡辺幸嗣 中條和子 鷲尾純平 飯島洋一 騎馬和歌子 吉岡靖介 前園葉月 米畑有里 西真紀子 高橋信博 翻訳
    • Related Report
      2013 Final Research Report
  • [Book] デンタルカリエス 原著第2版 その病態と臨床マネージメント、第21章、 第23章2013

    • Author(s)
      高橋信博・恵比須繁之 監訳, 山口幹代 青葉孝昭 景山正登 大野純一 岩見行晃 木本敦 稲葉大輔 佐野哲也 佐藤拓一 渡部茂 渡辺幸嗣 中條和子 鷲尾純平 飯島洋一 騎馬和歌子 吉岡靖介 前園葉月 米畑有里 西真紀子 高橋信博 翻訳
    • Total Pages
      30
    • Publisher
      医歯薬出版
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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