Development of new pulp conservative treatment with soy isoflavones and flax lignans
| Project/Area Number |
24792031
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Tohoku University (2014)
Health Sciences University of Hokkaido (2012-2013) |
|---|
Principal Investigator |
HANDA Keisuke 東北大学, 歯学研究科(研究院), 講師 (40433429)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 大豆イソフラボン / 歯髄細胞 / 直接覆髄 / 石灰化 / 直接覆髄実験 / Akt / p38 / ELISA法 / ゲニステイン |
|---|
| Outline of Final Research Achievements |
In this study, the genistein with estrogen-like effect is added to the rat dental pulp cells to be examined mineralization ability. and also reparative dentin inducing ability was tested by rat direct pulp capping experiments.By genistein addition to rat dental pulp cells, ALPase activity, alizarin red staining positive and hard tissue formation associated genes expression was increased. And more high quality reparative dentin formation and minor pulpal response was observed by direct pulp capping experiments.
These results indicated genistein induces calcification of rat dental pulp cells, was suggested may be useful as a direct pulp capping agent.
|
Report
(4 results)
Research Products
(15 results)
