| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The present study clarified that tooth replantation/transplantation induced the apoptosis of odontoblasts and the subsequent differentiation of dental pulp stem cells (DPSCs) into the odontoblasts following active cell proliferation, whereas bone formation occurred if the DPSCs degenerated. Due to the migration of non-inherent pulpal cells into the pulp chamber and the transient increase of Wnt signaling in the perivascular niche of the center of pulp tissue, suggesting the involvement of Wnt signal for the maintenance of DPSCs. Thus, dynamic donor-host or pulp-periodontal tissue interactions induce the drastic changes in pulp cell populations following tooth replantation/transplantation.
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