Calcium phosphate-alginate-calcium sulfate composite for bone regeneration

• Project/Area Number: 24792054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Tohoku University
• Principal Investigator: FUJI Takeshi 東北大学, 歯学研究科(研究院), 助教 (20549323)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アルギン酸 / リン酸カルシウム / 硫酸カルシウム / 骨再建 / 骨芽細胞 / 歯学 / 骨再生

Research Abstract

We past established a method and conditions to prepare alginate/ calcium sulfate composites contain calcium phosphate most efficiently. But this method is poorly-reproducible, so we looked at the effect of the experimental technique. Then we can make the same composites constantly with osteogenic ability from calcium phosphate and its form. The results suggest that this composites has potential to provide a better scaffold in bone defect regardless its size or shape.