Research Project
Grant-in-Aid for Young Scientists (B)
In this study, we report that large-magnitude (12%) cyclic stretch induced Ca2+ influx in MC3T3-E1 osteoblasts, which subsequently activated ASK1 MAP3K. The activated ASK1-JNK lead to transiently enhanced expression of FGF-inducible 14 (Fn14, a member of the TNF receptor superfamily) gene. Cells with enhanced expression of Fn14 subsequently acquired sensitivity to the ligand of Fn14, TNF-related weak inducer of apoptosis, and underwent apoptosis. On the other hand, ASK1-p38 pathway induced expression of monocyte chemoattractant protein-3 (MCP-3) gene, which promoted chemotaxis of pre-osteoclasts. These results suggest that ASK1-JNK/p38 pathways contribute to the mechanism of mechanical overloading-induced bone resroption via cytokine-related gene expression.
All 2014 2012
All Journal Article (6 results) (of which Peer Reviewed: 6 results, Open Access: 1 results) Book (3 results)
J. Biol. Chem
Volume: 289 Pages: 6438-6450
J. Biol. Chem.
Volume: 289 Issue: 10 Pages: 6438-6450
10.1074/jbc.m113.536300
FEBS Letters
Volume: 586(19) Pages: 3024-9
Genes and Cancer
Volume: 3(5-6) Pages: 394-401
CLINICAL CALCIUM
Volume: Vol.22 No.12(doi:CliCa121218551862) Pages: 1855-1862
Volume: 3 Issue: 5-6 Pages: 394-401
10.1177/1947601912461443