| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In oro-facial region, it is well known that Dry-Eye, Dry-nose, Dry-mouth syndrome as DRY syndrome. Three regions, the ocular surface, the intraoral cavity and the intranasal cavity, require constant secretions to provide nourishment and a protective barrier to the external environment. For Dry-Eye, cornea primary afferent neurons that respond to drying of the ocular surface have been previously characterized and found to respond to innocuous cooling, menthol and hyperosmotic stimuli. In this project, I have focused on the desensitization of primary afferent neuron which decreased the BASAL tearing and performed whole project to know this modulatory mechanisms. As a result, TRPV1 agonist, Capsaicin suppressed the corneal TRPM8-related neural activity (desensitization). It is proposed that there were some interaction between TRPM8 channel and TRPV1 channel on corneal primary afferent.
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