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Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha

Research Project

Project/Area Number 24792084
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionOkayama University

Principal Investigator

UEDA Mayu  岡山大学, 大学病院, 医員 (20625719)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsTNF-α / 歯髄細胞 / 幹細胞化
Research Abstract

The purpose of this study is to investigate the effects of a treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human dental pulp cells, and elucidate of the mechanism of dentin regeneration.
In conclusion, our data show that a short-term treatment with TNF-alpha significantly increases the stem cell phenotype of DPCs as well as their function and multipotent differentiation ability. Additionally, our findings also demonstrate that the reprogramming depend on TNF-alpha specifically and NF-kB is not the only pathway involved in the TNF-alpha-enhanced stem cell phenotype of DPCs.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results)

  • [Journal Article] A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells2014

    • Author(s)
      Mayu Ueda, Takuo Fujisawa, Mitsuaki Ono, Emilio Satoshi Hara, Hai Thanh Pham, Ryu Nakajima, Wataru Sonoyama, Takuo Kuboki
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 5 Issue: 1 Pages: 31-31

    • DOI

      10.1186/scrt420

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] A short-term treatment with TNF-α enhances the stem cell phenotype of human dental pulp cells2013

    • Author(s)
      Pham HT. Ueda M, Fujisawa T, Ono M, Hara ES, Sonoyama W, Pham LV, Kuboki T
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research (IBMSC-JSBMR)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] A short-term treatment with TNF-α enhances the stem cell phenotype of human dental pulp cells.2013

    • Author(s)
      Pham HT
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research.
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] A comparative analysis of the effect of rhTNF-α treatment on the stem cell phenotype of cells derived from dental pulp, periodontal ligament and bone marrow2012

    • Author(s)
      Pham TH, Ono M, Hara ES, Ueda M, Sonoyama W, Lieu PV, Kuboki T
    • Organizer
      The Asean Plus and Tokushima Joint International Conference
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of transient TNF-α treatment on the stem cell phenotype of human periodontal ligament cells and bone marrow stromal cells2012

    • Author(s)
      Pham TH, Ono M, Hara ES, Ueda M, Sonoyama W, Lieu PV, Kuboki T
    • Organizer
      第10回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2012-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Human Dental Pulp Cells Increase Stem Cell-like Phenotype By TNF-α2012

    • Author(s)
      Ueda M, Fujisawa T, Ono M, Masaki A, Miki H, Sonoyama W, Kuboki T
    • Organizer
      90th General Session & Exhibition of the IADR
    • Place of Presentation
      Iguacu Falls, Brazil
    • Year and Date
      2012-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症環境による歯髄細胞の幹細胞化-歯髄細胞分化に与えるTNF-αの影響-2012

    • Author(s)
      上枝麻友, 藤澤拓生, 大野充昭, 正木明日香, 三木春奈, 園山 亘, 窪木拓男
    • Organizer
      平成24年度社団法人日本補綴歯科学会第121回学術大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症環境による歯髄細胞の幹細胞化 ―歯髄細胞分化に与えるTNF-αの影響―.2012

    • Author(s)
      上枝麻友
    • Organizer
      平成24年度社団法人日本補綴歯科学会第121回学術大会.
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Human Dental Pulp Cells Increase Stem Cell-like Phenotype By TNF-α.2012

    • Author(s)
      Ueda M
    • Organizer
      90th General Session & Exhibition of the IADR.
    • Place of Presentation
      Iguacu Falls
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of transient TNF-α treatment on the stem cell phenotype of human periodontal ligament cells and bone marrow stromal cells.2012

    • Author(s)
      Pham TH
    • Organizer
      Japanese Association of Regenerative Dentistry 10th annual meeting.
    • Place of Presentation
      Kobe
    • Related Report
      2012 Research-status Report
  • [Presentation] A comparative analysis of the effect of rhTNF-α treatment on the stem cell phenotype of cells derived from dental pulp, periodontal ligament and bone marrow.2012

    • Author(s)
      Pham TH
    • Organizer
      The Asean Plus and Tokushima Joint International Conference
    • Place of Presentation
      Yogyakarta
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯髄細胞のリプログラミングに対するTNF-αの効果2011

    • Author(s)
      上枝麻友, 藤澤拓生, 大野充昭, 正木明日香, 三木春奈, 園山 亘, 窪木拓男
    • Organizer
      平成23年度社団法人日本補綴歯科学会中国・四国支部学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2011-09-04
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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