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Development of novel treatment on masticatory muscle pain with TMD

Research Project

Project/Area Number 24792116
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionNihon University

Principal Investigator

NOMA Noboru  日本大学, 歯学部, 准教授 (70386100)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords持続的咬筋収縮 / ATP / 咬筋痛覚過敏 / P2X3受容体 / 圧痛閾値 / バイオルミネッセンス解析
Research Abstract

The mean percentage of FG-labeled P2X3R-positive neurons was significantly increased in TG following successive IL-1beta injections into the MM for 7 days. Successive administration of an IL-1beta receptor-antagonist into the MM attenuated the increase of P2X3-IR cells in the TG. ATP release from MM after 300-g pressure stimulation of MM was also significantly enhanced after CMM. Administration into MM of the selective P2X3,2/3 receptor antagonist A-317491 attenuated the decrement of HWT in CMM rats. A significant increase in HWT was also observed at 30 min after A-317491 (60 µg) injection in IL-1beta-injected rats. These findings suggest that P2X3R expression associated with enhanced IL-1beta expression and ATP release in MM has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 11 results) Presentation (7 results) Book (2 results)

  • [Journal Article] 口腔顔面領域における特発性疼痛(総説)2013

    • Author(s)
      野間 昇, 森蔭 直広, 今村 佳樹
    • Journal Title

      ペインクリニック

      Volume: 34巻2号 Pages: 233-241

    • Related Report
      2013 Final Research Report
  • [Journal Article] Interaction of IL-1 β and P2X3 Receptor in Pathologic Masseter Muscle Pain2013

    • Author(s)
      Noma N, Shinoda M, Honda K, Kiyomoto M, Dezawa K, Nakaya Y, Komiyama O, Imamura Y, Iwata K
    • Journal Title

      J Dent Res

      Volume: 92(5) Pages: 456-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stellate ganglion block as an early intervention in sympathetically maintained headache and orofacial pain caused by temporal arteritis2013

    • Author(s)
      Noma N, Kamo H, Nakaya Y, Dezawa K, Young A, Khan J, Imamura Y
    • Journal Title

      Pain Med

      Volume: 14(3) Pages: 392-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fractalkine signaling in microglia contributes to ectopic orofacial pain following trapezius muscle inflammation.2013

    • Author(s)
      Kiyomoto M, Shinoda M, Okada-Ogawa A, Noma N, Shibuta K, Tsuboi Y, Sessle BJ, Imamura Y, Iwata K
    • Journal Title

      J Neurosci

      Volume: 33 Issue: 18 Pages: 7667-80

    • DOI

      10.1523/jneurosci.4968-12.2013

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immune and Endocrine Function in Patients with Burning Mouth Syndrome2013

    • Author(s)
      Koike K, Shinozaki T, Hara K, Noma N, Okada-Ogawa A, Asano M, Shinoda M, Eliav E, Gracely RH, Iwata K, Imamura Y
    • Journal Title

      Clin J Pain

      Volume: 30(2) Pages: 168-73

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats2013

    • Author(s)
      Teramoto K, Tsuboi Y, Shinoda M, Hitomi S, Abe K, Kaji K, Tamagawa T, Suzuki A, Noma N, Kobayashi M, Komiyama O, Urata K, Iwata K
    • Journal Title

      Eur J Oral Sci

      Volume: 121(2) Pages: 86-91

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-nociceptive effect of IL-12p40 in a rat model of neuropathic pain2013

    • Author(s)
      Chen IF, Khan J, Noma N, Hadlaq E, Teich S, Benoliel R, Eliav E
    • Journal Title

      Cytokine. Jun

      Volume: Cytokine. Jun Pages: 401-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Groupcognitive-behavioral intervention for patients with burning mouth syndrome2013

    • Author(s)
      Komiyama O, Nishimura H, Makiyama Y, Iida T, Obara R, Shinoda M, Kobayashi M, Noma N, Abe O, De Laat A, Kawara M
    • Journal Title

      J Oral Sci

      Volume: 55(1) Pages: 17-22

    • NAID

      130003366646

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of oral function in acute and recovery phase of idiopathic facial palsy ; a preliminary controlled study2013

    • Author(s)
      Kato Y, Kamo H, Kobayashi A, Abe S, Okada-Ogawa A, Noma N, Kukimoto N, Omori H, Nakazato H, Kishi H, Ikeda M, Imamura Y
    • Journal Title

      Clin Otolaryngol

      Volume: 38(3) Pages: 231-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 日常臨床における「噛み合わせ日記」活用の誘い2013

    • Author(s)
      松本邦史, 野間 昇, 今村佳樹, 本田和也
    • Journal Title

      The Quintessence

      Volume: Vol.32.N0.8 Pages: 35-37

    • Related Report
      2013 Final Research Report
  • [Journal Article] Interaction of IL-1β and P2X3 receptor in pathologic masseter muscle pain.2013

    • Author(s)
      Noma N, Shinoda M, Honda K, Kiyomoto M, Dezawa K, Nakaya Y, Komiyama O, Imamura Y, Iwata K
    • Journal Title

      J Dent Res,

      Volume: 92 Issue: 5 Pages: 456-460

    • DOI

      10.1177/0022034513483770

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia2012

    • Author(s)
      Komiyama O, Obara R, Uchida T, Nishimura H, Iida T, Okubo M, Shimosaka M, Narita N, Niwa H, Shinoda M, Kobayashi M, Noma N, Abe O, Makiyama Y, Hirayama T, Kawara M
    • Journal Title

      J Oral Sci

      Volume: 54(4) Pages: 321-7

    • NAID

      130003318540

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔顔面痛2012

    • Author(s)
      野間 昇
    • Journal Title

      Practice of Pain Management

      Volume: 12月号Vol.3 No.4 Pages: 18-21

    • Related Report
      2013 Final Research Report
  • [Journal Article] 難治性顔面痛の診断と治療2012

    • Author(s)
      今村 佳樹, 岡田 明子, 野間 昇, 篠崎貴弘
    • Journal Title

      口腔領域からみた難治性顔面痛(解説/特集) : 神経内科

      Volume: 77巻5号 Pages: 456-461

    • Related Report
      2013 Final Research Report
  • [Journal Article] Topical Pregabalin and Diclofenac for the Treatment of Neuropathic Orofacial Pain in Rats2012

    • Author(s)
      Plaza-Villegas F, Heir G, Markman S, Khan J, Noma N, Benoliel R, Patel J, Eliav E
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 114(4) Pages: 449-56

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ラット咬筋痛におけるP2X3 受容体およびIL-1βの関与2013

    • Author(s)
      野間 昇, 篠田 雅路, 今村 佳樹, 岩田幸一
    • Organizer
      日本疼痛学会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット咬筋痛におけるP2X3 受容体およびIL-1βの関与2013

    • Author(s)
      野間 昇、篠田雅路、今村佳樹、岩田幸一
    • Organizer
      第35回日本疼痛学会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット咬筋圧痛におけるATP, IL-6, IL-1βの関与2012

    • Author(s)
      野間 昇, 出澤 幸, 篠田雅路, 岩田幸一, 今村佳樹
    • Organizer
      日本口腔顔面痛学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット咬筋圧痛におけるATP, IL-6, IL-1βの関与2012

    • Author(s)
      出澤幸, 野間昇, 原 和彦, 大澤憲二, 今村佳樹
    • Organizer
      日本口腔診断学会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of ATP, IL-6 and IL-1beta in rat model of masseter muscle pathological pain2012

    • Author(s)
      Noboru Noma, Yoshiki Imamura, Masamichi Shinoda, Koichi Iwata
    • Organizer
      IASP
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Hemicrania continua in a patient with concomitant dental disease

    • Author(s)
      Noboru Noma
    • Organizer
      The 14th Scientific Meeting of Asian Academy of CranioMandibular Disorders
    • Place of Presentation
      GIS NTU Convention Center,Taiwan
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of ATP, IL-6, and IL-1β in a rat model of pathological pain in masseter muscle

    • Author(s)
      Noboru Noma
    • Organizer
      Neuroscience Meeting 2012
    • Place of Presentation
      New Orleans, at the convention center,USA
    • Related Report
      2012 Research-status Report
  • [Book] 顎関節症. 痛みの診療 ベストプラクティス. 小川節郎, 牛田亨宏編2014

    • Author(s)
      野間 昇
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] 非ステロイド性抗炎症薬(NSAIDs)口腔顔面痛の診断と治療 ガイドブック, 日本口腔顔面痛学会 編2013

    • Author(s)
      野間 昇
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2023-03-16  

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