Development of novel treatment on masticatory muscle pain with TMD

• Project/Area Number: 24792116
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Nihon University
• Principal Investigator: NOMA Noboru 日本大学, 歯学部, 准教授 (70386100)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 持続的咬筋収縮 / ATP / 咬筋痛覚過敏 / P2X3受容体 / 圧痛閾値 / バイオルミネッセンス解析

Research Abstract

The mean percentage of FG-labeled P2X3R-positive neurons was significantly increased in TG following successive IL-1beta injections into the MM for 7 days. Successive administration of an IL-1beta receptor-antagonist into the MM attenuated the increase of P2X3-IR cells in the TG. ATP release from MM after 300-g pressure stimulation of MM was also significantly enhanced after CMM. Administration into MM of the selective P2X3,2/3 receptor antagonist A-317491 attenuated the decrement of HWT in CMM rats. A significant increase in HWT was also observed at 30 min after A-317491 (60 µg) injection in IL-1beta-injected rats. These findings suggest that P2X3R expression associated with enhanced IL-1beta expression and ATP release in MM has a possible important role in MM mechanical hyperalgesia after excessive muscular contraction.

Research Products

• [Journal Article] 口腔顔面領域における特発性疼痛(総説) (2013)
  • Author(s): 野間 昇, 森蔭 直広, 今村 佳樹
  • Journal Title: ペインクリニック Volume: 34巻2号 Pages: 233-241
• [Journal Article] Interaction of IL-1 β and P2X3 Receptor in Pathologic Masseter Muscle Pain (2013)
  • Author(s): Noma N, Shinoda M, Honda K, Kiyomoto M, Dezawa K, Nakaya Y, Komiyama O, Imamura Y, Iwata K
  • Journal Title: J Dent Res Volume: 92(5) Pages: 456-60
  • Peer Reviewed
• [Journal Article] Stellate ganglion block as an early intervention in sympathetically maintained headache and orofacial pain caused by temporal arteritis (2013)
  • Author(s): Noma N, Kamo H, Nakaya Y, Dezawa K, Young A, Khan J, Imamura Y
  • Journal Title: Pain Med Volume: 14(3) Pages: 392-7
  • Peer Reviewed
• [Journal Article] Fractalkine signaling in microglia contributes to ectopic orofacial pain following trapezius muscle inflammation. (2013)
  • Author(s): Kiyomoto M, Shinoda M, Okada-Ogawa A, Noma N, Shibuta K, Tsuboi Y, Sessle BJ, Imamura Y, Iwata K
  • Journal Title: J Neurosci Volume: 33 Issue: 18 Pages: 7667-80
  • DOI: 10.1523/jneurosci.4968-12.2013
  • Peer Reviewed
• [Journal Article] Immune and Endocrine Function in Patients with Burning Mouth Syndrome (2013)
  • Author(s): Koike K, Shinozaki T, Hara K, Noma N, Okada-Ogawa A, Asano M, Shinoda M, Eliav E, Gracely RH, Iwata K, Imamura Y
  • Journal Title: Clin J Pain Volume: 30(2) Pages: 168-73
  • Peer Reviewed
• [Journal Article] Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats (2013)
  • Author(s): Teramoto K, Tsuboi Y, Shinoda M, Hitomi S, Abe K, Kaji K, Tamagawa T, Suzuki A, Noma N, Kobayashi M, Komiyama O, Urata K, Iwata K
  • Journal Title: Eur J Oral Sci Volume: 121(2) Pages: 86-91
  • Peer Reviewed
• [Journal Article] Anti-nociceptive effect of IL-12p40 in a rat model of neuropathic pain (2013)
  • Author(s): Chen IF, Khan J, Noma N, Hadlaq E, Teich S, Benoliel R, Eliav E
  • Journal Title: Cytokine. Jun Volume: Cytokine. Jun Pages: 401-6
  • Peer Reviewed
• [Journal Article] Groupcognitive-behavioral intervention for patients with burning mouth syndrome (2013)
  • Author(s): Komiyama O, Nishimura H, Makiyama Y, Iida T, Obara R, Shinoda M, Kobayashi M, Noma N, Abe O, De Laat A, Kawara M
  • Journal Title: J Oral Sci Volume: 55(1) Pages: 17-22
  • NAID: 130003366646
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of oral function in acute and recovery phase of idiopathic facial palsy ; a preliminary controlled study (2013)
  • Author(s): Kato Y, Kamo H, Kobayashi A, Abe S, Okada-Ogawa A, Noma N, Kukimoto N, Omori H, Nakazato H, Kishi H, Ikeda M, Imamura Y
  • Journal Title: Clin Otolaryngol Volume: 38(3) Pages: 231-6
  • Peer Reviewed
• [Journal Article] 日常臨床における「噛み合わせ日記」活用の誘い (2013)
  • Author(s): 松本邦史, 野間 昇, 今村佳樹, 本田和也
  • Journal Title: The Quintessence Volume: Vol.32.N0.8 Pages: 35-37
• [Journal Article] Interaction of IL-1β and P2X3 receptor in pathologic masseter muscle pain. (2013)
  • Author(s): Noma N, Shinoda M, Honda K, Kiyomoto M, Dezawa K, Nakaya Y, Komiyama O, Imamura Y, Iwata K
  • Journal Title: J Dent Res, Volume: 92 Issue: 5 Pages: 456-460
  • DOI: 10.1177/0022034513483770
  • Peer Reviewed
• [Journal Article] Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia (2012)
  • Author(s): Komiyama O, Obara R, Uchida T, Nishimura H, Iida T, Okubo M, Shimosaka M, Narita N, Niwa H, Shinoda M, Kobayashi M, Noma N, Abe O, Makiyama Y, Hirayama T, Kawara M
  • Journal Title: J Oral Sci Volume: 54(4) Pages: 321-7
  • NAID: 130003318540
  • Peer Reviewed
• [Journal Article] 口腔顔面痛 (2012)
  • Author(s): 野間 昇
  • Journal Title: Practice of Pain Management Volume: 12月号Vol.3 No.4 Pages: 18-21
• [Journal Article] 難治性顔面痛の診断と治療 (2012)
  • Author(s): 今村 佳樹, 岡田 明子, 野間 昇, 篠崎貴弘
  • Journal Title: 口腔領域からみた難治性顔面痛(解説/特集) : 神経内科 Volume: 77巻5号 Pages: 456-461
• [Journal Article] Topical Pregabalin and Diclofenac for the Treatment of Neuropathic Orofacial Pain in Rats (2012)
  • Author(s): Plaza-Villegas F, Heir G, Markman S, Khan J, Noma N, Benoliel R, Patel J, Eliav E
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 114(4) Pages: 449-56
  • Peer Reviewed
• [Presentation] ラット咬筋痛におけるP2X3 受容体およびIL-1βの関与 (2013)
  • Author(s): 野間 昇, 篠田 雅路, 今村 佳樹, 岩田幸一
  • Organizer: 日本疼痛学会
  • Place of Presentation: 埼玉
• [Presentation] ラット咬筋痛におけるP2X3 受容体およびIL-1βの関与 (2013)
  • Author(s): 野間 昇、篠田雅路、今村佳樹、岩田幸一
  • Organizer: 第35回日本疼痛学会
  • Place of Presentation: 大宮ソニックシティ(埼玉県）
• [Presentation] ラット咬筋圧痛におけるATP, IL-6, IL-1βの関与 (2012)
  • Author(s): 野間 昇, 出澤 幸, 篠田雅路, 岩田幸一, 今村佳樹
  • Organizer: 日本口腔顔面痛学会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-03
• [Presentation] ラット咬筋圧痛におけるATP, IL-6, IL-1βの関与 (2012)
  • Author(s): 出澤幸, 野間昇, 原 和彦, 大澤憲二, 今村佳樹
  • Organizer: 日本口腔診断学会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-14
• [Presentation] Involvement of ATP, IL-6 and IL-1beta in rat model of masseter muscle pathological pain (2012)
  • Author(s): Noboru Noma, Yoshiki Imamura, Masamichi Shinoda, Koichi Iwata
  • Organizer: IASP
  • Place of Presentation: Milan, Italy
• [Presentation] Hemicrania continua in a patient with concomitant dental disease
  • Author(s): Noboru Noma
  • Organizer: The 14th Scientific Meeting of Asian Academy of CranioMandibular Disorders
  • Place of Presentation: GIS NTU Convention Center,Taiwan
• [Presentation] Involvement of ATP, IL-6, and IL-1β in a rat model of pathological pain in masseter muscle
  • Author(s): Noboru Noma
  • Organizer: Neuroscience Meeting 2012
  • Place of Presentation: New Orleans, at the convention center,USA
• [Book] 顎関節症. 痛みの診療 ベストプラクティス. 小川節郎, 牛田亨宏編 (2014)
  • Author(s): 野間 昇
  • Publisher: メディカルレビュー社
• [Book] 非ステロイド性抗炎症薬(NSAIDs)口腔顔面痛の診断と治療 ガイドブック, 日本口腔顔面痛学会 編 (2013)
  • Author(s): 野間 昇
  • Publisher: 医歯薬出版株式会社