Elucidation of the recovery mechanism from stress response in the brain caused by malocclusion.

• Project/Area Number: 24792118
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthetic dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: OTSUKA TAKERO 神奈川歯科大学, 歯学研究科(研究院), 助教 (40516754)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ニューロイメージング / 不正咬合 / ストレス / fMRI / NIRS / 咬合不全 / 光トポグラフィ

Outline of Final Research Achievements

Our previous functional magnetic resonance imaging (fMRI) study have suggested that malocclusion affects the emotional state of brain regions, such a limbic area or prefrontal cortex (PFC).　In this experiment, functional near-infrared spectroscopy (fNIRS) of the PFC could be used to objectively evaluate the occlusal condition. Because the fNIRS device is easier to control than other neuroimaging methods, it is more suitable for evaluating the occlusal condition in clinical settings.

Research Products

• [Journal Article] Influence of restoration adjustments on prefrontal blood flow (2015)
  • Author(s): Sasaguri K, Otsuka T, Tsunashima H, Shimazaki T, Kubo KY, Onozuka M
  • Journal Title: International Journal of stomatology & occlusion medicine Volume: 8 Issue: 1 Pages: 22-28
  • DOI: 10.1007/s12548-015-0122-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Correlation of hypothalamic activation with malocclusion: An fMRI study (2015)
  • Author(s): Otsuka T, Hayashi Y, Sasaguri K, Kawata T
  • Journal Title: Biomedical Research Volume: 26 Pages: 203-206
  • Peer Reviewed
• [Journal Article] Effect of articulatory rehabilitation after oral cancer surgery on higher brain activation (2014)
  • Author(s): Okada N, Sasaguri K, Otsuka T, Fujita A, Ito H, Noguchi T, Jinbu Y, Kusama M
  • Journal Title: International Journal of Oral & Maxillofacial Surgery Volume: 43 Pages: 933-940
  • Peer Reviewed
• [Journal Article] Effect of articulatory rehabilitation after oral cancer surgery on higher brain activation. (2014)
  • Author(s): Okada N, Sasaguri K, Otsuka T, Fujita A, Ito H, Noguchi T, Jinbu Y, Kusama M
  • Journal Title: Int J Oral Maxillofac Surg. Volume: in press Issue: 8 Pages: 933-940
  • DOI: 10.1016/j.ijom.2014.02.013
  • Peer Reviewed
• [Journal Article] Medical-grade collagen peptide in injectables provides antioxidant protection. (2013)
  • Author(s): Kobayashi K, Maehata Y, Okada Y, Kusubata M, Hattori S, Tanaka K, Miyamoto C, Yoshino F, Yoshida A, Tokutomi F, Wada-Takahashi S, Komatsu T, Otsuka T, Takahashi SS, Lee MC
  • Journal Title: Pharmaceutical Development and Technology Volume: online Issue: 2 Pages: 1-8
  • DOI: 10.3109/10837450.2013.860547
  • Peer Reviewed / Open Access
• [Journal Article] The mandibular response to occlusal relief using a flat guidance splint. (2013)
  • Author(s): Reichardt G, Miyakawa Y, Otsuka T, Sato S
  • Journal Title: Int J Stomatol Occlusion Med Volume: ６ Issue: 4 Pages: 134-139
  • DOI: 10.1007/s12548-013-0093-8
  • Peer Reviewed
• [Journal Article] Vertical facial height and its correlation with facial width and depth: Three dimensional cone beam computed tomography evaluation based on dry skulls. (2013)
  • Author(s): Wang MF, Otsuka T, Akimoto S, Sato S
  • Journal Title: Int J Stomatol Occlusion Med Volume: 6 Issue: 4 Pages: 120-129
  • DOI: 10.1007/s12548-013-0089-4
  • Peer Reviewed
• [Journal Article] 矯正歯科治療はDr. Edward H. Angle のような天才が現れないと進歩しないのか？―ブラケットとワイヤーの時代からそれを使わない矯正治療の時代へ―. (2013)
  • Author(s): 河田俊嗣, 小泉創, 大塚剛郎, 小田博夫, 長谷川信, 岩田敏男
  • Journal Title: Aging Science Volume: 6 Pages: 48-52
  • Peer Reviewed
• [Journal Article] Effect of anesthesia on trigeminal somatosensory evoked magnetic fields. (2012)
  • Author(s): Otsuka, T., Dan, H., Dan, I., Sase, M., Sano, T., Tsuzuki, D., Sasaguri, K., Okada, N., Kusama, M., Jinbu, Y., Watanabe, E.
  • Journal Title: Journal of Dental Research Volume: 91(12) Issue: 12 Pages: 1196-201
  • DOI: 10.1177/0022034512462398
  • Peer Reviewed
• [Journal Article] Dental resin curing blue light induced oxidative stress with reactive oxygen species production (2012)
  • Author(s): Yoshino F, Yoshida A, Okada E, Okada Y, Maehata Y, Miyamoto C, Kishimoto S, Otsuka T, Nishimura T, Lee M-C
  • Journal Title: Journal of Photochemistry and Photobiology B : Biology Volume: 114 Pages: 73-78
  • DOI: 10.1016/j.jphotobiol.2012.05.012
  • Peer Reviewed
• [Journal Article] Comparison of brain activation via tooth stimulation. (2012)
  • Author(s): Shimazaki T, Otsuka T, Akimoto S, Kubo KY, Sato S, Sasaguri K.
  • Journal Title: Jornal od Dental Reserch Volume: 91 Issue: 8 Pages: 759-763
  • DOI: 10.1177/0022034512450880
  • Peer Reviewed
• [Presentation] The Effects of Occlusal Interference on Brain Activation by fMRI. (2015)
  • Author(s): K. Sasaguri, T. Otsuka, T. Kawata
  • Organizer: 93rd General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Boston, USA
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] 下歯槽神経麻痺患者の麻痺状態の客観的評価法：脳磁図による検討 (2014)
  • Author(s): 大塚剛郎, 笹栗健一, 神部芳則, 檀一平太, 小田博雄, 岩田敏男, 河田俊嗣
  • Organizer: 第73回日本矯正歯科学会大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-10-20 – 2014-10-22
• [Presentation] Tooth contact and brain function. (2014)
  • Author(s): T. Otsuka, K. Sasaguri, T. Kawata
  • Organizer: 90th congress of the european orthodontic society
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2014-06-18 – 2014-06-21
• [Presentation] 口腔機能と健康長寿；ニューロイメージングによる考察. (2014)
  • Author(s): 大塚剛郎
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-06-06 – 2014-06-08
  • Invited
• [Presentation] Effect of local anesthesia on trigeminal somatosensory-evoked magnetic fields. (2013)
  • Author(s): Otsuka T, Dan H, Dan I, Sase M, SanoT, Tsuzuki D, Fujita A, Okada N, Watanabe E, Kusama M, Sasaguri K, Jinbu Y
  • Organizer: FDI Annual World Dental Congress
  • Place of Presentation: Istanbul
• [Presentation] 実験的咬合干渉の有無による脳賦活状態の検討. (2013)
  • Author(s): 林勇大, 大塚剛郎, 丹羽政美, 笹栗健一, 秋本進, 河田俊嗣
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 脳磁図による下歯神経槽機能障害とその回復過程の客観的評価. (2013)
  • Author(s): 大塚剛郎, 神部芳則, 草間幹夫, 笹栗健一, 秋本進, 河田俊嗣
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 歯周病における唾液中活性酸素の作用 –Down症候群患者における検討–. (2013)
  • Author(s): 小松知子, 大塚剛郎, 高野知子, 宮城敦, 李昌一
  • Organizer: 日本老年歯科医学会第24回学術大会
  • Place of Presentation: 大阪
• [Presentation] 実験的咬合干渉の有無による脳賦活状態の検討. (2013)
  • Author(s): 林勇大, 大塚剛郎, 笹栗健一, 河田俊嗣
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 顎後方偏位時における前頭前野の賦活近赤外線分光法による検討. (2013)
  • Author(s): 山崎隆一, 大塚剛郎, 島崎盾詩, 林勇大 ,笹栗健一, 河田俊嗣
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 脳磁図による下歯槽機能障害の客観的評価 (2013)
  • Author(s): 大塚 剛郎、神部芳則、草間幹夫、 笹栗健一、秋本進
  • Organizer: 第140回神奈川歯科大学学会例会
  • Place of Presentation: 横須賀
• [Presentation] Effect of local anesthesia on trigeminal somatosensory-evoked magnetic fields (2013)
  • Author(s): Takero Otsuka, Haruka Dan, Ippeita Dan, Miwako Sase, Toshifumi Sano, Daisuke Tsuzuki, Akifumi Fujita, Naruo Okada, Eiju Watanabe, Mikio Kusama, Kenichi Sasaguri, Yoshinori Jinbu
  • Organizer: IADR Annual Meeting
  • Place of Presentation: Seattle Wash
• [Presentation] 大規模災害時における口腔ケアの客観的評価法の確立 (2013)
  • Author(s): 大塚剛郎、小松知子、李 昌一
  • Organizer: 第１回 災害医療歯科学研究報告会
  • Place of Presentation: 横須賀
• [Presentation] Cortical Activation Resulting from Different Tooth Stimulation Measured by NIRS. (2012)
  • Author(s): Tateshi Shimazaki, Takero Otsuka, Sadao Sato, Kenichi Sasaguri
  • Organizer: ICME CME 2012 Conference
  • Place of Presentation: 神戸
• [Presentation] 歯の刺激に伴う大脳皮質賦活の歯種における比較 (2012)
  • Author(s): 島崎盾詩、大塚剛郎、笹栗健一、秋本進
  • Organizer: 第71回東京矯正歯科学会学術大会
  • Place of Presentation: 東京
• [Presentation] 脳磁図による下歯槽神経機能障害の客観的評価 (2012)
  • Author(s): 大塚剛郎、檀はるか、檀一平太、佐瀬美和子、佐野俊文、續木大介、笹栗健一、岡田成生、渡辺英寿3）、神部芳則、草間幹夫
  • Organizer: 第11回自治医科大学シンポジウム
  • Place of Presentation: 下野
• [Presentation] Tooth Contact and Brain Activity (2012)
  • Author(s): Tateshi Shimazaki, Takero Otsuka, Kenichi Sasaguri, Sadao Sato
  • Organizer: IJC-MEAW
  • Place of Presentation: 横浜
• [Presentation] 脳磁図による下歯槽神経機能障害の客観的評価 (2012)
  • Author(s): 大塚 剛郎、佐瀬 美和子、神部 芳則、笹栗 健一、岡田 成生、檀 はるか、渡辺 英寿、佐野 俊文、續木 大介、檀 一平太、草間 幹夫
  • Organizer: 第35回 神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 実験的咬合干渉の有無による脳賦活状態の検討 (2012)
  • Author(s): 林勇大、大塚剛郎、山崎隆一、笹栗健一、秋本進
  • Organizer: 第139回神奈川歯科大学学会例会
  • Place of Presentation: 横須賀
• [Presentation] 脳磁図による下歯神経槽機能障害の客観的評価.
  • Author(s): 大塚剛郎, 神部芳則, 草間幹夫, 笹栗健一, 秋本進, 河田俊嗣
  • Organizer: 第72回東京矯正歯科学会学術大会
  • Place of Presentation: 東京
• [Presentation] 下歯槽神経麻痺患者の麻痺状態の客観的評価法：脳磁図による検討.
  • Author(s): 大塚剛郎, 笹栗健一, 神部芳則, 草間幹夫, 河田俊嗣
  • Organizer: 第143回神奈川歯科大学学会例会
  • Place of Presentation: 横須賀
• [Presentation] 簡易なESR法による放射線被曝線量法測定法の 確立のための基礎的研究とヒトへの応用 第2報.
  • Author(s): 李昌一, 斉田牧子, 小林杏, 吉田彩佳, 大塚剛郎, 小松知子, 櫻井孝, 三宅実, Harold M. Swartz, 吉野文彦
  • Organizer: 第二回災害医療歯科学研究報告会
  • Place of Presentation: 横須賀
• [Presentation] 大規模災害時における口腔ケアの客観的評価法の確立.
  • Author(s): 大塚剛郎, 小松知子, 河田俊嗣, 李 昌一
  • Organizer: 第二回災害医療歯科学研究報告会
  • Place of Presentation: 横須賀