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Hydrothermal treatment of titanium implant surface with calcium promotes epithelial sealing

Research Project

Project/Area Number 24792122
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionKyushu University (2013-2014)
Fukuoka Dental College (2012)

Principal Investigator

YAMAZOE Jyunichi  九州大学, 歯学研究科(研究院), 研究員 (30452717)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsカルシウム水熱処理 / インプラント / 口腔インプラント / カルシウム修飾 / 水熱カルシウム処理 / チタン / 間葉系幹細胞 / チタン合金 / 水熱処理 / 骨伝導性 / 歯科インプラント
Outline of Final Research Achievements

Improvement of oral epithelial adhesion to titanium (Ti) may significantly enhance the efficacy of dental implants. We aimed to investigate whether CaCl2 hydrothermal-treated (Ca-HT) Ti could promote sealing of the peri-implant epithelium (PIE) around the implant. Right maxillary first molars were extracted from rats and replaced with either Ca-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group) or non-treated implants (Cont group). We also investigated the effect of Ca-HT on the attachment of rat oral epithelial cells (OECs). OEC adherence on Ca-HT Ti plates was stronger, with greater expression levels of adhesion proteins, compared with Cont and DW-HT groups. These results indicated that HT with CaCl2 improved the integration of soft tissue cells with Ti, which may facilitate the development of a soft tissue barrier around the implant.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Promoting effect of CaCl2 hydrothermal treatment to titanium implant surface for early epithelial sealing2015

    • Author(s)
      Wakana Oshiro, Yasunori Ayukawa*, Ikiru Atsuta, Akihiro Furuhashi, Jyunichi Yamazoe, Ryosuke Kondo, Mami Sakaguchi, Yuri Matsuura, Yoshihiro Tsukiyama, Kiyoshi Koyano
    • Journal Title

      Colloids&surfaces B Bioninterfaces

      Volume: 0 Pages: 0-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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