| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
To establish the analytical method and the maintenance in the bone strength after prosthesis we firstly examined the effect of MS on relationships between chemokine expression and osteoclastogenesis using hyperocclusion models. MS induced by intermittent stretching upregulated the expression of CCL2. We secondly examined the effect of aging changes on production of collagens in bone quality of the PDL tissue by excess MS. The expression of collagen type XII in young and aged mice also increased in stimulus time dependent manner. Hyperocclusion predominantly induced CCL2 expression in PDL tissues and promoted chemotaxis and osteoclastogenesis, leading to MS-dependent alveolar bone destruction during occlusal traumatism. Furthermore, expression of collagen type XII has been suggested may be involved in homeostasis and stability of the PDL fibers, resulting in the maintenance of jaw bone quality.
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