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Establishment of the analytical method of the change of alveolar bone strength of the osteoporosis and hyperocclusion

Research Project

Project/Area Number 24792125
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionFukuoka College of Health Sciences

Principal Investigator

GOTO-T KAZUKO  福岡医療短期大学, その他部局等, 准教授 (60389418)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords骨強度 / 骨粗鬆症 / 顎骨 / 咬合力 / ケモカイン / コラーゲン
Outline of Final Research Achievements

To establish the analytical method and the maintenance in the bone strength after prosthesis we firstly examined the effect of MS on relationships between chemokine expression and osteoclastogenesis using hyperocclusion models. MS induced by intermittent stretching upregulated the expression of CCL2. We secondly examined the effect of aging changes on production of collagens in bone quality of the PDL tissue by excess MS. The expression of collagen type XII in young and aged mice also increased in stimulus time dependent manner. Hyperocclusion predominantly induced CCL2 expression in PDL tissues and promoted chemotaxis and osteoclastogenesis, leading to MS-dependent alveolar bone destruction during occlusal traumatism. Furthermore, expression of collagen type XII has been suggested may be involved in homeostasis and stability of the PDL fibers, resulting in the maintenance of jaw bone quality.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice.2013

    • Author(s)
      Tsutsumi T, Kajiya H, Goto KT, Takahashi Y, Okabe K.
    • Journal Title

      J Dent Res.

      Volume: 92(1) Pages: 65-70

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] •メカニカルストレスによる歯根膜組織のコラーゲン産生能の加齢による変化2014

    • Author(s)
      都築 尊,鍛冶屋 浩, 後藤 加寿子, 堤 貴司, 岡部 幸司
    • Organizer
      日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] The novel roles of CCL2 and CCL3 on osteoclast differentiation and alveolar bone resorption during occlusal traumatism.2013

    • Author(s)
      Tsutsumi T, Kajiya H, Goto K, Nagaoka Y, Okamoto F, Okabe K.
    • Organizer
      国際骨代謝学会(IBMS)・日本骨代謝学会(JSBMR)第2回合同国際会議
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of C-C chemokine ligands for osteoclastogenesis induced by hyperocclusion.2013

    • Author(s)
      Tsutsumi T, Kajiya H, Goto K, Takahashi Y, Okabe K.
    • Organizer
      アメリカ骨代謝学会
    • Place of Presentation
      アメリカ ボルチモア
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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