Fundamental research on the material development of high biocompatibility applying tannic acid

• Project/Area Number: 24792128
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: NAKAMURA Koichi 北海道大学, 歯学研究科(研究院), 助教 (50580932)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: タンニン酸 / 抗炎症作用 / 細胞毒性

Research Abstract

Glass ionomer cement have a fluoride-releasing.It is said that pulp affinity is high. At first, We examined for the presence of cytotoxic.It was found that COX-2 mRNA expression was induced by cement elution.Tannic acid suppressed the phenomenon. The increased expression of COX-2 mRNA and protein and the production of PGE2 by cement elution. Furthermore, activation of intracellular signal transduction systems present in the upstream was observed. Tannic acid was found to suppress them.