| Project/Area Number |
24792136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 液中プラズマ放電 / ナノ・ディンプル / 歯科インプラント / 口腔粘膜上皮細胞 / 液中プラズマ |
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| Research Abstract |
The peri-implantitis, which is induced by poor epithelial attachment to the implant surface, often causes the removal of implant. In this study, we first developed titanium having nano-dimples on the surface by means of the plasma discharge in aqueous solution, referred to as "in-liquid discharge Ti". Since in-liquid discharge Ti is a novel material and its properties have not fully investigated, we examined the ability of oral mucosa keratinocytes to attach the surface of in-liquid discharge Ti under two- and three-dimensional cell culture environment. As a result, we were able to coat the titanium surface with nanometer order dimples by means of the plasma discharge in aqueous solution. Our results also showed the cell proliferation and biocompatibility of the titanium surface. Furthermore, it was confirmed that epithelium did not detach from in-liquid discharge Ti even if the cell-attachment environment of titanium and epithelium was poor.
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