| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Cancer cells have extremely high growth activity. Previously, it was understood that the activity is supported by activated HIF1 via glucose metabolic mechanism under tumor specific hypoxic condition. But, clinical study comparing FDG-PET to FMISO-PET showed the cases that had highly activated metabolic capacity even without hypoxia.
In this study, we stained HIF1, Ki67, GLUT1 in all the metastatic lymph nodes from over 2000 of operative enucleated cervical lymph nodes.
All three factors expressed abundantly in tumor specific manor. HIF1 expression pattern was unrelated to oxygen gradient from blood vessels. These results suggest that tumor specific hyper-activation of HIF1 is partially regulate glucose transporter expression and has more direct relation to cancer cell's special growth activity.
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