The study of objective capture indicators stress reaction due to pain

• Project/Area Number: 24792169
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: KURIHARA jun 東北大学, 歯学研究科(研究院), 助教 (10508899)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 術後痛 / ストレス反応 / 唾液αアミラーゼ活性 / PAR-2 / 肥満細胞 / プロテアーゼ活性化受容体 / トリプターゼ / 国際情報交換

Outline of Final Research Achievements

By considering the objective and withstand indicators stress response by pain, aimed at suppression of the early post-operative pain. Salivary α-amylase activity may potentially can become objective stress markers have been suggested. Future it also considered to require additional examination. Also, tryptase from mast cells bind to PAR-2 which is present in the free nerve endings of primary afferent fibers, neurogenic inflammation induced by activated. PAR-2 are involved in the establishment of early postoperative pain, later it thinks that other factors are involved. As a future research agenda, it is planned to study.