Development of new therapy for bone healing and regeneration using inflammatory stimuli.
| Project/Area Number |
24792170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Henmi Akiko 東北大学, 歯学研究科, 助教 (40613055)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 骨欠損修復 / 炎症 / NF-κB / 頭蓋骨 / ラット / コラーゲン担体 / 石灰化 / 歯学 / NF－κB / 骨形成 / ＮＦ－κB |
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| Outline of Final Research Achievements |
The study was designed to test the hypothesis that bone healing is advanced by inflammation and decreased when the inflammation is down-regulated. We attempted to develop the rat experimental model. The collagen carriers were implanted in a rat parietal bone defect and the process of degradation of the carrier was examined in 1 day, 3 days and 1 week. The most of the carrier was degraded within 1 day and completely disappeared within three days. Bone formation in the defect was compared in 4 weeks with histology between the experimental rat and the control, a rat with no carrier in the defect. The most of the bone defect healed in the control whereas little bone formation was observed in the defect with the collagen carrier. How to apply the collagen carrier to the bone defect remains to be considered. The rat experimental model of the secondary bone defect and that of the decoy for NF-κB have not been made and are still under consideration.
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Report
(6 results)
Research Products
(18 results)
