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Development of new therapy for bone healing and regeneration using inflammatory stimuli.

Research Project

Project/Area Number 24792170
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

Henmi Akiko  東北大学, 歯学研究科, 助教 (40613055)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords骨欠損修復 / 炎症 / NF-κB / 頭蓋骨 / ラット / コラーゲン担体 / 石灰化 / 歯学 / NF-κB / 骨形成 / NF-κB
Outline of Final Research Achievements

The study was designed to test the hypothesis that bone healing is advanced by inflammation and decreased when the inflammation is down-regulated. We attempted to develop the rat experimental model. The collagen carriers were implanted in a rat parietal bone defect and the process of degradation of the carrier was examined in 1 day, 3 days and 1 week. The most of the carrier was degraded within 1 day and completely disappeared within three days. Bone formation in the defect was compared in 4 weeks with histology between the experimental rat and the control, a rat with no carrier in the defect. The most of the bone defect healed in the control whereas little bone formation was observed in the defect with the collagen carrier. How to apply the collagen carrier to the bone defect remains to be considered. The rat experimental model of the secondary bone defect and that of the decoy for NF-κB have not been made and are still under consideration.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Analysis of calcium, phosphorus, and carbon concentrations during developmental calcification of dentin and enamel in rat incisors using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX).2016

    • Author(s)
      Maruyama K, Henmi A, Okata H, Sasano Y
    • Journal Title

      Journal of Oral Biosciences

      Volume: 58 Issue: 4 Pages: 173-179

    • DOI

      10.1016/j.job.2016.08.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone matrix calcification during embryonic and postembryonic rat calvarial development assessed by SEM-EDX, XRD and FTIR.2015

    • Author(s)
      Henmi A, Okata H, Anada T, Yoshinari M, Mikami Y, Suzuki O, Sasano Y
    • Journal Title

      J Bone Miner Metab

      Volume: in press Issue: 1 Pages: 41-50

    • DOI

      10.1007/s00774-014-0647-x

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Calcification during bone healing in a standardised rat calvarial defect assessed by micro- CT and SEM- EDX2014

    • Author(s)
      Okata H, Nakamura M, Henmi A, Yamaguchi S, Mikami Y, Shimauchi H, Sasano Y
    • Journal Title

      Oral Diseases

      Volume: in press Issue: 1 Pages: 74-82

    • DOI

      10.1111/odi.12212

    • Related Report
      2015 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of the calcification process modeled in rat embryonic calvarial culture2011

    • Author(s)
      Kimura Y, Kikunaga S, Takahashi I, Hatakeyama Y, Fukumoto S, Sasano Y
    • Journal Title

      J Electron Microsc

      Volume: 60 Issue: 5 Pages: 345-52

    • DOI

      10.1093/jmicro/dfr068

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ラット切歯象牙質とエナメル質の形成過程におけるカルシウム、リンおよび炭素のSEM-EDXを用いた元素分析2016

    • Author(s)
      逸見晶子、丸山顕太郎、大方広志、笹野泰之
    • Organizer
      日本解剖学会 第62回東北・北海道連合支部学術集会
    • Place of Presentation
      帯広市
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨の発生・修復に伴う石灰化成熟2016

    • Author(s)
      笹野 泰之、逸見 晶子、大方 広志、中村 恵、鈴木 治
    • Organizer
      第121回日本解剖学会総会・全国学術集会、シンポジウム「石灰化研究の新展開」
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] SEM-EDX analysis of Ca, P and C during calcification in rat incisor dentin and enamel.2016

    • Author(s)
      Maruyama K, Henmi A, Okata H, Sasano Y
    • Organizer
      The 6th International Symposiumfor Interface Oral Health Science.
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2016-01-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット切歯エナメル質と象牙質の石灰化過程におけるCa, PおよびCのSEM-EDX分析2014

    • Author(s)
      丸山顕太郎,逸見 晶子,笹野 泰之
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡市、福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 骨発生・成長における石灰化過程の解析2013

    • Author(s)
      逸見 晶子、大方 広志、穴田 貴久、三上 靖人、鈴木 治、笹野 泰之
    • Organizer
      日本解剖学会 第59回東北・北海道連合支部学術集会
    • Place of Presentation
      北海道大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ANALYSIS OF CALCIFICATION IN BONE HEALING WITH A STANDARDISED RAT CALVARIAL DEFECT MODEL2013

    • Author(s)
      Okata H, Nakamura M, Henmi A, Yamaguchi S, Mikami Y, Shimauchi H, Sasano Y
    • Organizer
      ASahct2013 International Symposium Anatomical Science for advance in health and clinical therapy
    • Place of Presentation
      Gonryo Kaikan hall, Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット頭蓋骨発生・成長過程における骨基質石灰化の成熟に関する検討2013

    • Author(s)
      逸見 晶子、大方 広志、三上 靖人、鈴木 治、笹野 泰之
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 林 利華、狐塚 雅弘、宍戸 駿一、柿内 裕輔、逸見 晶子、大方 広志、笹野 泰之2013

    • Author(s)
      ラット下顎骨発生における石灰化
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] Calcification in the bone matrix during rat calvarial development

    • Author(s)
      Henmi A, Okata H, Anada T, Yoshinari M, Mikami Y, Suzuki O, Sasano Y
    • Organizer
      The 6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Calcification in healing calvarial bone assessed by micro-CT and SEM-EDX

    • Author(s)
      Okata H, Nakamura M, Henmi A, Yamaguchi S, Sasano Y
    • Organizer
      The 6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Calcification in rat developing mandibular bone

    • Author(s)
      Hayashi R, Kozuka M, Shishido S, Kakiuchi Y, Henmi A, Okata H, Sasano Y
    • Organizer
      The 6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 硬組織の発生・修復における細胞外基質リモデリングと石灰化

    • Author(s)
      笹野 泰之、逸見 晶子,大方 広志、三上 靖人、中村 恵
    • Organizer
      第118回日本解剖学会総会・全国学術集会 研究集会・懇話会
    • Place of Presentation
      高松市
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨密度と構成元素の解析を利用した修復骨基質の石灰化の検討

    • Author(s)
      大方広志、中村 恵、逸見晶子、島内英俊、笹野泰之
    • Organizer
      第58回東北・北海道連合支部学術集会
    • Place of Presentation
      山形市
    • Related Report
      2012 Research-status Report
  • [Presentation] 骨欠損修復における骨基質の石灰化に関する検討

    • Author(s)
      大方広志、中村 恵、逸見晶子、島内英俊、笹野泰之
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島県郡山市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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