Effect of low intensity pulsed ultrasound on bone formation.

Research Project

Project/Area Number	24792177
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Dokkyo Medical University (2014) The University of Tokyo (2012-2013)
Principal Investigator	YUSKE Komiyama 獨協医科大学, 医学部, 助教 (90586471)
Co-Investigator(Renkei-kenkyūsha)	ABE Takahiro 東京大学, 医学部付属病院顎口腔外科歯科矯正歯科, 講師 (20383250)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	低出力超音波パルス / 骨芽細胞 / 破骨細胞 / 骨代謝 / LIPUS / 破骨細胞分化 / 骨芽細胞分化 / ex vivo culture
Outline of Final Research Achievements	Low intensity pulsed ultrasound stimulation is known to directly stimulate pre-osteoblastic cells to osteoblastogenesis, though increase the bone formation. In this study, we aimed to investigate the effect of LIPUS on bone metabolism, including effects on both osteoblasts and osteoclasts. LIPUS could enhance the osteoclastogenesis of pre-osteoclast under the addition of differentiation factor. Bone metabolism is understood to be controlled through signaling from both osteoblasts and osteoclasts. Osteoclast-to-osteoblast signaling may be also have important roll in the effect of bone formation by LIPUS.