| Project/Area Number |
24792188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
KOJIMA Taku 新潟大学, 医歯学系, 助教 (90515777)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨再生 / バイオマテリアル / 間葉系幹細胞 / 骨芽細胞 / 破骨細胞 / 骨細胞 / 骨質 |
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| Research Abstract |
We examined bone regeneration induce by a porous beta-TCP block mingled with bone marrow stromal cells, in order to clarify histological events during the bone regeneration and to assess bone quality in this model. New bone showed a histological profile of compact bone, and was composed of densely packed collagen fibrils that were orderly arranged. The mineralization of the new bone was sufficient. Thus, these results showed that beta-TCP block mingled with differentiated bone marrow stromal cells had a high osteogenic potential, and therefore, the resultant bone regenerated by this technique appears to possess good bone quality.
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