Effects of angiogenesis inhibitor and fibroblast growth inhibitor on invasion and metastasis of oral squamous cell carcinoma.
| Project/Area Number |
24792195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔扁平上皮癌 / 増殖抑制 / 線維芽細胞増殖抑制剤 / シスプラチン / 血管新生阻害剤 / 浸潤 / 転移 / 血管新生阻害薬 |
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| Research Abstract |
Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and fibroblast growth inhibitor and antiangiogenic agent on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OLC-01, OSC-19 was implanted into the tongue of nude mice, and cisplatin or tranilast or avastin were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor size and stroma collagen fiber content were significantly reduced in conbination group of cisplatin and tranilast. And tumor stroma were changed charactaristic in conbination group. Lymph node matastasis and vascularization were significantly reduced in avastin group.
The use of anticancer agent and fibroblast growth inhibitor and antiangiogenic agent considering these effects may be clinically very useful.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Loss of claudin-7 is a negative prognostic factor for invasion andmetastasis in oral squamous cell carcinoma2013
Author(s)
Yoshizawa K., Nozaki S., Kato A., Hirai M., Yanase M., Yoshimoto T., KimuraI., Sugiura .S, Okamune A., Kitahara H., Noguchi N., Kato K., Ueki K., Kawashiri S
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Journal Title
Oncology Report
Volume: 29
Issue: 2
Pages: 445-450
DOI
Related Report
Peer Reviewed
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[Presentation] 口腔扁平上皮癌におけるCaveolin-1 発現に関する免疫組織化学的検討2013
Author(s)
加藤広禄, 平井真理子, 加藤阿希, 木村依世, 柳瀬瑞希, 杉浦史郎, 岡宗絢子, 北原寛子, 野口夏代, 吉澤邦夫, 中村博幸, 川尻 秀 一
Organizer
第58回日本口腔外科学会総会・学術大会
Place of Presentation
福岡国際会議場 ・マリンメッセ福岡(福岡県)
Year and Date
2013-10-11
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[Presentation] AMPK 活性化薬剤による口腔扁平上皮癌の抗腫瘍効果の検討2012
Author(s)
加藤広禄, 野口夏代, 吉澤邦夫, 北原寛子, 岡宗絢子, 杉浦史郎, 木村依世, 柳瀬瑞希, 加藤阿希, 平井真理子, 川尻秀一
Organizer
第57回日本口腔外科学会総会・学術大会
Place of Presentation
パシフィコ横浜 (神奈川県)
Year and Date
2012-10-20
Related Report
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[Presentation] Claudin-7 expression as a prognostic factor correlates with mode of invasion in oral squamous cell carcinoma2012
Author(s)
Yoshizawa, K., Sugiura, S., Okamune, A., Kitahara, H., Noguchi, N., Kato, K., Kawashiri, S
Organizer
17th World congress on advances in oncology and 15th International symposium on molecular medicine
Place of Presentation
Creta(Greece)
Year and Date
2012-10-12
Related Report
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