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Can anti-angiogenic drug improve prognosis in CDDP resistant cell of oral cancer?

Research Project

Project/Area Number 24792208
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

ISHIBASHI Miki  大阪大学, 歯学研究科(研究院), 招聘教員 (40412051)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords抗血管新生 / 口腔癌 / 抗がん剤耐性
Research Abstract

The aim of this study was to clarify the sensibility of anti-angiogenesis therapy in CDDP-resistant oral squamous cell carcinomas. Briefly, ANG-1, ANG-2, VEGF, CD31 were immunohistochemically examined in order to evaluate its correlation with 3 type of human oral squamous cell carcinoma cell lines. We did not find significant correlation immunohistochemically with ANG-1, ANG-2 between human oral squamous cell carcinomas and CDDP-resistant oral squamous cell carcinomas. The sensibility of chemoradiotherapy in human oral squamous cell carcinomas after chemo-radiotherapy depend on, suggesting the involvement of other factors.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2014 2013

All Presentation (7 results)

  • [Presentation] 血管柄付き遊離腓骨皮弁で再建を行った下顎正中エナメル上皮腫の1例2014

    • Author(s)
      石橋美樹, 相川友直, 住岡 聡, 磯村恵美子, 沢井奈津子, 美馬孝至, 古郷幹彦
    • Organizer
      第32回日本口腔腫瘍学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 上唇に生じた血管平滑筋腫の1例2013

    • Author(s)
      住岡聡, 石橋美樹, 美馬孝至
    • Place of Presentation
      兵庫
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] MTX 関連リンパ増殖性疾患と考えられた舌悪性リンパ腫の1例2013

    • Author(s)
      石橋美樹, 住岡 聡, 美馬孝至
    • Organizer
      第58回日本口腔外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 顎下腺原発腺様嚢胞癌の多発性肺転移症例にS-1を投与しQOLの維持が得られた1例2013

    • Author(s)
      石橋美樹, 香川一史, 美馬孝至
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] MTX関連リンパ増殖性疾患と考えられた舌悪性リンパ腫の1例2013

    • Author(s)
      住岡聡、石橋美樹、美馬孝至
    • Organizer
      第58回日本口腔外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 上唇に生じた血管平滑筋腫の1例2013

    • Author(s)
      住岡聡、石橋美樹、美馬孝至
    • Organizer
      第44回日本口腔外科学会近畿支部学術集会
    • Place of Presentation
      兵庫
    • Related Report
      2013 Annual Research Report
  • [Presentation] 顎下腺原発腺様嚢胞癌の多発性肺転移症例にS-1を投与しQOLの維持が得られた1例2013

    • Author(s)
      石橋美樹、香川一史、美馬孝至
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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