Development of gene therapy for oral cancer mediated by Naked DNA of molecule processing E-cadherin

• Project/Area Number: 24792218
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: HAMANA Tomoaki 広島大学, 医歯薬保健学研究院(歯), 助教 (40397922)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: α２－アンチプラスミン / プラスミン / E-カドヘリン / Naked DNA / 口腔癌遺伝子治療 / α2ーアンチプラスミン / Eーカドヘリン / Eｰカドヘリン / α2ｰアンチプラスミン

Research Abstract

This study showed that oral cancer cells transferred gene of alpha2-antiplasmin (alpha2-AP) which is plasmin inhibitor were remarkably suppressed in vivo tumor formation and expression of E-cadherin increased in the formed tumor. The results suggest that inducing of alpha2-AP protein suppresses tumor invasion and metastasis by increasing not only proteolytic activity but also cell migration and proliferation. Therefor, it is expected the development of novel gene therapy by inducing of alpha2-AP for oral cancer.

Research Products

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  • URL: http://seeds.hiroshima-u.ac.jp/soran/e5h7e55/index.html